The carcinogenicity, mutagenicity, and toxicity of arsenic and cadmium
Thesis (S.M. in Molecular Systems Toxicology)--Massachusetts Institute of Technology, Biological Engineering Division, 2004.
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| Format: | Thesis |
| Language: | eng |
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Massachusetts Institute of Technology
2007
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| Online Access: | http://hdl.handle.net/1721.1/35699 |
| _version_ | 1826204242397888512 |
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| author | Lai, Leslie, 1981- |
| author2 | Leona D. Samson and Peter C. Dedon. |
| author_facet | Leona D. Samson and Peter C. Dedon. Lai, Leslie, 1981- |
| author_sort | Lai, Leslie, 1981- |
| collection | MIT |
| description | Thesis (S.M. in Molecular Systems Toxicology)--Massachusetts Institute of Technology, Biological Engineering Division, 2004. |
| first_indexed | 2024-09-23T12:51:10Z |
| format | Thesis |
| id | mit-1721.1/35699 |
| institution | Massachusetts Institute of Technology |
| language | eng |
| last_indexed | 2024-09-23T12:51:10Z |
| publishDate | 2007 |
| publisher | Massachusetts Institute of Technology |
| record_format | dspace |
| spelling | mit-1721.1/356992019-04-11T09:56:04Z The carcinogenicity, mutagenicity, and toxicity of arsenic and cadmium Lai, Leslie, 1981- Leona D. Samson and Peter C. Dedon. Massachusetts Institute of Technology. Biological Engineering Division. Massachusetts Institute of Technology. Biological Engineering Division. Biological Engineering Division. Thesis (S.M. in Molecular Systems Toxicology)--Massachusetts Institute of Technology, Biological Engineering Division, 2004. Includes bibliographical references (leaves 38-43). Recent epidemiological data has indicated that chronic exposure to metals such as arsenic and cadmium increases the risk of cancer and other diseases. These metals may have negative biological effects on cells by disrupting homeostatic cellular processes and altering normal signal transduction. One possible mechanism for many of these negative effects may involve overproduction of reactive oxygen species that damage proteins, lipids, carbohydrates, and nucleic acids. To compound this oxidative damage, there is evidence consistent with the inhibition of repair of damaged DNA by these metals. As a result, there is an increase in mutagenicity and toxicity in the organisms. This thesis reviews the current literature relevant to the biochemistry and biology of arsenic and cadmium. by Leslie Lai. S.M.in Molecular Systems Toxicology 2007-01-10T21:01:32Z 2007-01-10T21:01:32Z 2004 2004 Thesis http://hdl.handle.net/1721.1/35699 57351067 eng MIT theses are protected by copyright. They may be viewed, downloaded, or printed from this source but further reproduction or distribution in any format is prohibited without written permission. http://dspace.mit.edu/handle/1721.1/7582 43 leaves 2564100 bytes 2566899 bytes application/pdf application/pdf application/pdf Massachusetts Institute of Technology |
| spellingShingle | Biological Engineering Division. Lai, Leslie, 1981- The carcinogenicity, mutagenicity, and toxicity of arsenic and cadmium |
| title | The carcinogenicity, mutagenicity, and toxicity of arsenic and cadmium |
| title_full | The carcinogenicity, mutagenicity, and toxicity of arsenic and cadmium |
| title_fullStr | The carcinogenicity, mutagenicity, and toxicity of arsenic and cadmium |
| title_full_unstemmed | The carcinogenicity, mutagenicity, and toxicity of arsenic and cadmium |
| title_short | The carcinogenicity, mutagenicity, and toxicity of arsenic and cadmium |
| title_sort | carcinogenicity mutagenicity and toxicity of arsenic and cadmium |
| topic | Biological Engineering Division. |
| url | http://hdl.handle.net/1721.1/35699 |
| work_keys_str_mv | AT laileslie1981 thecarcinogenicitymutagenicityandtoxicityofarsenicandcadmium AT laileslie1981 carcinogenicitymutagenicityandtoxicityofarsenicandcadmium |