Multivariate Perturbation of a Growth Factor-Cytokine Signalling Network Reveals Complex Systemic Responses in Glioblastoma Cells

Multivariate Perturbation of a Growth Factor-Cytokine Signalling Network Reveals Complex Systemic Responses in Glioblastoma Cells

Glioblastoma cells can evade TRAIL-induced apoptosis through various strategies involving the growth factor-activated MEK–MAPK/ERK and PI3K–Akt/PKB pro-survival signalling cascades. Although these signalling cascades have been studied extensively, our understanding of how they interact and participa...

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Bibliographic Details
Main Authors: Tang, Yew Chung, Wan, Guoqiang, Stephanopoulos, Gregory, Too, Heng-Phon
Format: Article
Language:English
Published: 2007
Subjects:
Signal Transduction
Network Biology
Apoptosis
Kinase Inhibitors
Online Access:http://hdl.handle.net/1721.1/35872

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