Synthesis and Complexation Behavior of Pluronic-b-Poly(acrylic Acid) Copolymer with Doxorubicin
Poly(acrylic acid) (PAA) was attached on both termini of Pluronic P85 copolymer (EO27PO39EO27)) via atom transfer radical polymerization (ATRP) to produce a novel block copolymer, PAA-b-P85-b-PAA (P85PAA). The P85PAA-DOX complex formation and drug loading were strongly dependent on the PAA segment a...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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2007
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| Online Access: | http://hdl.handle.net/1721.1/35873 |
| _version_ | 1826215567082651648 |
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| author | Tian, Y. Tam, Michael K. C. Hatton, T. Alan Bromberg, Lev |
| author_facet | Tian, Y. Tam, Michael K. C. Hatton, T. Alan Bromberg, Lev |
| author_sort | Tian, Y. |
| collection | MIT |
| description | Poly(acrylic acid) (PAA) was attached on both termini of Pluronic P85 copolymer (EO27PO39EO27)) via atom transfer radical polymerization (ATRP) to produce a novel block copolymer, PAA-b-P85-b-PAA (P85PAA). The P85PAA-DOX complex formation and drug loading were strongly dependent on the PAA segment and pH, where the protonation of the carboxyl groups in the PAA segment at pH<7.2 reduced the binding sites of DOX onto P85PAA chains, resulting less DOX uptake at low pH. The composition of the copolymer-DOX complexes that at pH 7.2 was close to the stoichiometric (1:1 mol Dox:carboxyl ratio), indicating the dominance of the electrostatic interactions between cationic DOX molecules and carboxyl groups. DOX loading at pH 5.0 reduced to 0.6:1 molar ratio of DOX:carboxyl indicated that protonation of the carboxyl reduced the DOX binding to the P85PAA block copolymer. DOX release from the complex is highly pH-responsive process, where 57% of encapsulated DOX was released in 30h at pH7.2, and the cumulative release fraction was accelerated to 95% by decreasing the pH to 5.0. Thus, complexation of DOX with P85PAA yielded a drug delivery system affording a pH-triggered release of DOX in acidic environment pH5.0. |
| first_indexed | 2024-09-23T16:35:31Z |
| format | Article |
| id | mit-1721.1/35873 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T16:35:31Z |
| publishDate | 2007 |
| record_format | dspace |
| spelling | mit-1721.1/358732019-04-13T00:09:08Z Synthesis and Complexation Behavior of Pluronic-b-Poly(acrylic Acid) Copolymer with Doxorubicin Tian, Y. Tam, Michael K. C. Hatton, T. Alan Bromberg, Lev Doxorubicin Atom Transfer Radical Polymerization Pluronic P85 Poly(acrylic acid) (PAA) was attached on both termini of Pluronic P85 copolymer (EO27PO39EO27)) via atom transfer radical polymerization (ATRP) to produce a novel block copolymer, PAA-b-P85-b-PAA (P85PAA). The P85PAA-DOX complex formation and drug loading were strongly dependent on the PAA segment and pH, where the protonation of the carboxyl groups in the PAA segment at pH<7.2 reduced the binding sites of DOX onto P85PAA chains, resulting less DOX uptake at low pH. The composition of the copolymer-DOX complexes that at pH 7.2 was close to the stoichiometric (1:1 mol Dox:carboxyl ratio), indicating the dominance of the electrostatic interactions between cationic DOX molecules and carboxyl groups. DOX loading at pH 5.0 reduced to 0.6:1 molar ratio of DOX:carboxyl indicated that protonation of the carboxyl reduced the DOX binding to the P85PAA block copolymer. DOX release from the complex is highly pH-responsive process, where 57% of encapsulated DOX was released in 30h at pH7.2, and the cumulative release fraction was accelerated to 95% by decreasing the pH to 5.0. Thus, complexation of DOX with P85PAA yielded a drug delivery system affording a pH-triggered release of DOX in acidic environment pH5.0. Singapore-MIT Alliance (SMA) 2007-02-06T12:00:00Z 2007-02-06T12:00:00Z 2007-01 Article http://hdl.handle.net/1721.1/35873 en Chemical and Pharmaceutical Engineering (CPE) application/pdf |
| spellingShingle | Doxorubicin Atom Transfer Radical Polymerization Pluronic P85 Tian, Y. Tam, Michael K. C. Hatton, T. Alan Bromberg, Lev Synthesis and Complexation Behavior of Pluronic-b-Poly(acrylic Acid) Copolymer with Doxorubicin |
| title | Synthesis and Complexation Behavior of Pluronic-b-Poly(acrylic Acid) Copolymer with Doxorubicin |
| title_full | Synthesis and Complexation Behavior of Pluronic-b-Poly(acrylic Acid) Copolymer with Doxorubicin |
| title_fullStr | Synthesis and Complexation Behavior of Pluronic-b-Poly(acrylic Acid) Copolymer with Doxorubicin |
| title_full_unstemmed | Synthesis and Complexation Behavior of Pluronic-b-Poly(acrylic Acid) Copolymer with Doxorubicin |
| title_short | Synthesis and Complexation Behavior of Pluronic-b-Poly(acrylic Acid) Copolymer with Doxorubicin |
| title_sort | synthesis and complexation behavior of pluronic b poly acrylic acid copolymer with doxorubicin |
| topic | Doxorubicin Atom Transfer Radical Polymerization Pluronic P85 |
| url | http://hdl.handle.net/1721.1/35873 |
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