Three-Dimensional Simulation of Carmustine Delivery to a Patient-Specific Brain Tumor
This study presents the recent development of three-dimensional patient-specific simulation of carmustine delivery to brain tumor that highlights several crucial factors affecting the delivery. The simulation utilizes the full-brain three-dimensional geometry constructed from magnetic resonance imag...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
2007
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| Subjects: | |
| Online Access: | http://hdl.handle.net/1721.1/35878 |
| _version_ | 1811086047297142784 |
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| author | Arifin, Davis Yohanes Wang, Chi-Hwa Smith, Kenneth A. |
| author_facet | Arifin, Davis Yohanes Wang, Chi-Hwa Smith, Kenneth A. |
| author_sort | Arifin, Davis Yohanes |
| collection | MIT |
| description | This study presents the recent development of three-dimensional patient-specific simulation of carmustine delivery to brain tumor that highlights several crucial factors affecting the delivery. The simulation utilizes the full-brain three-dimensional geometry constructed from magnetic resonance images (MRI) of a brain tumor patient. Prior to the simulation with tumor, the baseline simulation is initially done to obtain the interstitial fluid homeostasis in the normal brain so that the real picture of brain fluid dynamics in human brain is obtained. The simulation is conducted by coupling equations of continuity, motion, and carmustine species conservation, which, in turn, are solved simultaneously to calculate pressure, flow, and drug concentration fields, respectively. Carmustine is delivered by using the commercially available Gliadel wafers following the surgical removal of the tumor. The possible effects of vasogenic edema (due to surgery trauma) to brain fluid dynamics is also included. Here, the compiled results highlight that the drug release profile is, if not more than, as important as the dosage and the possible increase of convection due to edema. This study also reveals that a new strategy, namely convection enhanced delivery (CED) is able to increase drug penetration by enhancing interstitial fluid convection; but, over-enhanced convection may cause toxicity complications to surrounding healthy tissue during later stages of treatment. |
| first_indexed | 2024-09-23T13:20:03Z |
| format | Article |
| id | mit-1721.1/35878 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T13:20:03Z |
| publishDate | 2007 |
| record_format | dspace |
| spelling | mit-1721.1/358782019-04-12T08:35:48Z Three-Dimensional Simulation of Carmustine Delivery to a Patient-Specific Brain Tumor Arifin, Davis Yohanes Wang, Chi-Hwa Smith, Kenneth A. Carmustine BCNU Gliadel Wafer Polymeric Delivery Convection Enhanced Delivery Brain Tumor Simulation Computational Fluid Dynamics This study presents the recent development of three-dimensional patient-specific simulation of carmustine delivery to brain tumor that highlights several crucial factors affecting the delivery. The simulation utilizes the full-brain three-dimensional geometry constructed from magnetic resonance images (MRI) of a brain tumor patient. Prior to the simulation with tumor, the baseline simulation is initially done to obtain the interstitial fluid homeostasis in the normal brain so that the real picture of brain fluid dynamics in human brain is obtained. The simulation is conducted by coupling equations of continuity, motion, and carmustine species conservation, which, in turn, are solved simultaneously to calculate pressure, flow, and drug concentration fields, respectively. Carmustine is delivered by using the commercially available Gliadel wafers following the surgical removal of the tumor. The possible effects of vasogenic edema (due to surgery trauma) to brain fluid dynamics is also included. Here, the compiled results highlight that the drug release profile is, if not more than, as important as the dosage and the possible increase of convection due to edema. This study also reveals that a new strategy, namely convection enhanced delivery (CED) is able to increase drug penetration by enhancing interstitial fluid convection; but, over-enhanced convection may cause toxicity complications to surrounding healthy tissue during later stages of treatment. Singapore-MIT Alliance (SMA) 2007-02-06T01:05:51Z 2007-02-06T01:05:51Z 2007-01 Article http://hdl.handle.net/1721.1/35878 en Chemical and Pharmaceutical Engineering (CPE) application/pdf |
| spellingShingle | Carmustine BCNU Gliadel Wafer Polymeric Delivery Convection Enhanced Delivery Brain Tumor Simulation Computational Fluid Dynamics Arifin, Davis Yohanes Wang, Chi-Hwa Smith, Kenneth A. Three-Dimensional Simulation of Carmustine Delivery to a Patient-Specific Brain Tumor |
| title | Three-Dimensional Simulation of Carmustine Delivery to a Patient-Specific Brain Tumor |
| title_full | Three-Dimensional Simulation of Carmustine Delivery to a Patient-Specific Brain Tumor |
| title_fullStr | Three-Dimensional Simulation of Carmustine Delivery to a Patient-Specific Brain Tumor |
| title_full_unstemmed | Three-Dimensional Simulation of Carmustine Delivery to a Patient-Specific Brain Tumor |
| title_short | Three-Dimensional Simulation of Carmustine Delivery to a Patient-Specific Brain Tumor |
| title_sort | three dimensional simulation of carmustine delivery to a patient specific brain tumor |
| topic | Carmustine BCNU Gliadel Wafer Polymeric Delivery Convection Enhanced Delivery Brain Tumor Simulation Computational Fluid Dynamics |
| url | http://hdl.handle.net/1721.1/35878 |
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