Superior semicircular canal dehiscence : auditory mechanisms
Thesis (Ph. D.)--Harvard-MIT Division of Health Sciences and Technology, 2006.
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| Format: | Thesis |
| Language: | eng |
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Massachusetts Institute of Technology
2007
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| Online Access: | http://hdl.handle.net/1721.1/36165 |
| _version_ | 1811078783625592832 |
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| author | Songer, Jocelyn Evelyn |
| author2 | John J. Rosowski and Saumil N. Merchant. |
| author_facet | John J. Rosowski and Saumil N. Merchant. Songer, Jocelyn Evelyn |
| author_sort | Songer, Jocelyn Evelyn |
| collection | MIT |
| description | Thesis (Ph. D.)--Harvard-MIT Division of Health Sciences and Technology, 2006. |
| first_indexed | 2024-09-23T11:05:06Z |
| format | Thesis |
| id | mit-1721.1/36165 |
| institution | Massachusetts Institute of Technology |
| language | eng |
| last_indexed | 2024-09-23T11:05:06Z |
| publishDate | 2007 |
| publisher | Massachusetts Institute of Technology |
| record_format | dspace |
| spelling | mit-1721.1/361652019-04-10T18:17:43Z Superior semicircular canal dehiscence : auditory mechanisms Superior SCD : auditory mechanisms Songer, Jocelyn Evelyn John J. Rosowski and Saumil N. Merchant. Harvard University--MIT Division of Health Sciences and Technology. Harvard University--MIT Division of Health Sciences and Technology. Harvard University--MIT Division of Health Sciences and Technology. Thesis (Ph. D.)--Harvard-MIT Division of Health Sciences and Technology, 2006. Includes bibliographical references. Superior semicircular canal dehiscence (SCD) syndrome is a recently defined clinical disorder in which patients present to the clinic with vestibular symptoms, auditory symptoms, or both. Understanding the effect of SCD, a hole in the bony superior canal, on hearing will broaden our understanding of the mechanics of the inner ear and lead to better diagnosis and treatment of SCD syndrome. We evaluate the effect of SCD on cochlear responses to both air- and bone- conducted sound. In chinchilla SCD produces reversible changes in cochlear potential: an increased sensitivity to bone-conducted sound and a decreased sensitivity to air-conducted sound. Such differences in air- and bone-conducted sound (air-bone gaps) are typically associated with a conductive hearing loss due to middle-ear pathology; however, a SCD is an inner-ear pathology. We hypothesize that the SCD acts as a 'third window' into the inner ear, shunting volume velocity away from the cochlea and through the dehiscent canal, altering cochlear responses to sound. To qualitatively evaluate this hypothesis we measured sound-induced fluid motion within the SCD as well as the effect of SCD on sound-induced stapes velocity and middle-ear input admittance. (cont.) Our results are consistent with the hypothesis that the SCD introduces a low-impedance shunt pathway. To quantitatively evaluate the third-window hypothesis we developed an anatomically and physiologically constrained lumped-element mechano-acoustic model that predicts the effect of SCD on cochlear responses. Our model also predicts the effect of anatomical variations, such as dehiscence size and location, on auditory sensitivity. This work demonstrates that an air-bone gap can be caused by pathological changes in inner-ear mechanics. Additionally, our model provides a framework that will be of direct clinical benefit in understanding the variable effects of SCD among patients. by Jocelyn E. Songer. Ph.D. 2007-02-21T11:49:40Z 2007-02-21T11:49:40Z 2006 2006 Thesis http://hdl.handle.net/1721.1/36165 73726375 eng M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. http://dspace.mit.edu/handle/1721.1/7582 159 p. application/pdf Massachusetts Institute of Technology |
| spellingShingle | Harvard University--MIT Division of Health Sciences and Technology. Songer, Jocelyn Evelyn Superior semicircular canal dehiscence : auditory mechanisms |
| title | Superior semicircular canal dehiscence : auditory mechanisms |
| title_full | Superior semicircular canal dehiscence : auditory mechanisms |
| title_fullStr | Superior semicircular canal dehiscence : auditory mechanisms |
| title_full_unstemmed | Superior semicircular canal dehiscence : auditory mechanisms |
| title_short | Superior semicircular canal dehiscence : auditory mechanisms |
| title_sort | superior semicircular canal dehiscence auditory mechanisms |
| topic | Harvard University--MIT Division of Health Sciences and Technology. |
| url | http://hdl.handle.net/1721.1/36165 |
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