Algorithms for simulating human pre-mRNA splicing decisions
Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2005.
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| Format: | Thesis |
| Language: | eng |
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Massachusetts Institute of Technology
2007
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| Online Access: | http://hdl.handle.net/1721.1/37066 |
| _version_ | 1811068354121695232 |
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| author | Rolish, Michael E. (Michael Edward) |
| author2 | Christopher B. Burge. |
| author_facet | Christopher B. Burge. Rolish, Michael E. (Michael Edward) |
| author_sort | Rolish, Michael E. (Michael Edward) |
| collection | MIT |
| description | Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2005. |
| first_indexed | 2024-09-23T07:54:46Z |
| format | Thesis |
| id | mit-1721.1/37066 |
| institution | Massachusetts Institute of Technology |
| language | eng |
| last_indexed | 2024-09-23T07:54:46Z |
| publishDate | 2007 |
| publisher | Massachusetts Institute of Technology |
| record_format | dspace |
| spelling | mit-1721.1/370662022-01-13T07:54:29Z Algorithms for simulating human pre-mRNA splicing decisions Rolish, Michael E. (Michael Edward) Christopher B. Burge. Massachusetts Institute of Technology. Dept. of Electrical Engineering and Computer Science. Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Electrical Engineering and Computer Science. Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2005. Includes bibliographical references (leaves 37-38). In this thesis, I developed a program, ExonScan, to simulate constitutive human pre-mRNA splicing. ExonScan includes several models for splicing components, including splice sites, exonic splicing enhancers, exonic splicing silencers, and intronic splicing enhancers. I used ExonScan to test various aspects of human splicing, including correlation of splicing signal strength with tissue expression levels, the effectiveness of experimentally determined exonic splicing silencers, and splice site identification. by Michael E. Rolish. M.Eng. 2007-04-03T17:08:01Z 2007-04-03T17:08:01Z 2005 2005 Thesis http://hdl.handle.net/1721.1/37066 82538091 eng M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. http://dspace.mit.edu/handle/1721.1/7582 38 leaves application/pdf Massachusetts Institute of Technology |
| spellingShingle | Electrical Engineering and Computer Science. Rolish, Michael E. (Michael Edward) Algorithms for simulating human pre-mRNA splicing decisions |
| title | Algorithms for simulating human pre-mRNA splicing decisions |
| title_full | Algorithms for simulating human pre-mRNA splicing decisions |
| title_fullStr | Algorithms for simulating human pre-mRNA splicing decisions |
| title_full_unstemmed | Algorithms for simulating human pre-mRNA splicing decisions |
| title_short | Algorithms for simulating human pre-mRNA splicing decisions |
| title_sort | algorithms for simulating human pre mrna splicing decisions |
| topic | Electrical Engineering and Computer Science. |
| url | http://hdl.handle.net/1721.1/37066 |
| work_keys_str_mv | AT rolishmichaelemichaeledward algorithmsforsimulatinghumanpremrnasplicingdecisions |