High resolution in-vivo electrode localization using microfocal X-rays.
Thesis (M. Eng. and S.B.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2006.
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| Format: | Thesis |
| Language: | eng |
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Massachusetts Institute of Technology
2007
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| Online Access: | http://hdl.handle.net/1721.1/37082 |
| _version_ | 1826209158155730944 |
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| author | Oreper, Daniel (Daniel G.) |
| author2 | James J. DiCarlo. |
| author_facet | James J. DiCarlo. Oreper, Daniel (Daniel G.) |
| author_sort | Oreper, Daniel (Daniel G.) |
| collection | MIT |
| description | Thesis (M. Eng. and S.B.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2006. |
| first_indexed | 2024-09-23T14:18:25Z |
| format | Thesis |
| id | mit-1721.1/37082 |
| institution | Massachusetts Institute of Technology |
| language | eng |
| last_indexed | 2024-09-23T14:18:25Z |
| publishDate | 2007 |
| publisher | Massachusetts Institute of Technology |
| record_format | dspace |
| spelling | mit-1721.1/370822019-04-10T09:05:34Z High resolution in-vivo electrode localization using microfocal X-rays. Oreper, Daniel (Daniel G.) James J. DiCarlo. Massachusetts Institute of Technology. Dept. of Electrical Engineering and Computer Science. Massachusetts Institute of Technology. Dept. of Electrical Engineering and Computer Science. Electrical Engineering and Computer Science. Thesis (M. Eng. and S.B.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2006. Statement of responsibility "by Daniel Oreper" taken from abstract, p. 1. Leaf 109 blank. Includes bibliographical references (leaf 108). Neuroscientists lack the ability to perform in-vivo electrode localization with high accuracy, especially in deep brain structures. The design, implementation and testing of a microfocal x-ray stereo system that offers an efficient, accurate, and relatively low-cost solution this localization problem is presented. The results indicate the ability to localize a targets to within -50 microns, in a brain-tissue-based frame. This accuracy is approximately twice as good as than the existing gold standard in electrophysiology (microlesions), and, unlike the microlesion method, the stereo microfocal x-ray method has important advantages. In particular, while only tens of neuronal recording sites can be reliably reconstructed with the microlesion method, microfocal x-ray method can be repeatedly performed to accurately estimate an essentially unlimited number of serial penetrations, and the localization results are available in nearly real time without animal sacrifice. M.Eng.and S.B. 2007-04-03T17:09:42Z 2007-04-03T17:09:42Z 2006 2006 Thesis http://hdl.handle.net/1721.1/37082 83299446 eng M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. http://dspace.mit.edu/handle/1721.1/7582 109 leaves application/pdf Massachusetts Institute of Technology |
| spellingShingle | Electrical Engineering and Computer Science. Oreper, Daniel (Daniel G.) High resolution in-vivo electrode localization using microfocal X-rays. |
| title | High resolution in-vivo electrode localization using microfocal X-rays. |
| title_full | High resolution in-vivo electrode localization using microfocal X-rays. |
| title_fullStr | High resolution in-vivo electrode localization using microfocal X-rays. |
| title_full_unstemmed | High resolution in-vivo electrode localization using microfocal X-rays. |
| title_short | High resolution in-vivo electrode localization using microfocal X-rays. |
| title_sort | high resolution in vivo electrode localization using microfocal x rays |
| topic | Electrical Engineering and Computer Science. |
| url | http://hdl.handle.net/1721.1/37082 |
| work_keys_str_mv | AT oreperdanieldanielg highresolutioninvivoelectrodelocalizationusingmicrofocalxrays |