Designer peptides to understand the mineralization of calcium salts
Recently, we reported the extraction, purification and amino acid sequence of ansocalcin, the major goose eggshell matrix protein. In vitro studies showed that ansocalcin induces spherical calcite crystal aggregates. We designed two peptides using the unique features of the sequence of ansocalcin an...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | en_US |
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2003
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| Online Access: | http://hdl.handle.net/1721.1/3779 |
| _version_ | 1826206956220579840 |
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| author | Ajikumar, Parayil Kumaran Lakshminarayanan, Rajamani Valiyaveettil, Suresh Kini, R. Manjunatha |
| author_facet | Ajikumar, Parayil Kumaran Lakshminarayanan, Rajamani Valiyaveettil, Suresh Kini, R. Manjunatha |
| author_sort | Ajikumar, Parayil Kumaran |
| collection | MIT |
| description | Recently, we reported the extraction, purification and amino acid sequence of ansocalcin, the major goose eggshell matrix protein. In vitro studies showed that ansocalcin induces spherical calcite crystal aggregates. We designed two peptides using the unique features of the sequence of ansocalcin and the role of these peptides in CaCO₃ crystallization was investigated. The peptides showed similar activities as compared to ansocalcin, but at a higher concentration. The full characterization of the peptides and a rational for the observed morphology for the calcite crystals are discussed in detail. |
| first_indexed | 2024-09-23T13:41:13Z |
| format | Article |
| id | mit-1721.1/3779 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T13:41:13Z |
| publishDate | 2003 |
| record_format | dspace |
| spelling | mit-1721.1/37792019-04-12T08:25:07Z Designer peptides to understand the mineralization of calcium salts Ajikumar, Parayil Kumaran Lakshminarayanan, Rajamani Valiyaveettil, Suresh Kini, R. Manjunatha biomineralization calcium carbonate crystallization oligopeptides Recently, we reported the extraction, purification and amino acid sequence of ansocalcin, the major goose eggshell matrix protein. In vitro studies showed that ansocalcin induces spherical calcite crystal aggregates. We designed two peptides using the unique features of the sequence of ansocalcin and the role of these peptides in CaCO₃ crystallization was investigated. The peptides showed similar activities as compared to ansocalcin, but at a higher concentration. The full characterization of the peptides and a rational for the observed morphology for the calcite crystals are discussed in detail. Singapore-MIT Alliance (SMA) 2003-12-08T15:11:56Z 2003-12-08T15:11:56Z 2003-01 Article http://hdl.handle.net/1721.1/3779 en_US Molecular Engineering of Biological and Chemical Systems (MEBCS); 3117212 bytes application/pdf application/pdf |
| spellingShingle | biomineralization calcium carbonate crystallization oligopeptides Ajikumar, Parayil Kumaran Lakshminarayanan, Rajamani Valiyaveettil, Suresh Kini, R. Manjunatha Designer peptides to understand the mineralization of calcium salts |
| title | Designer peptides to understand the mineralization of calcium salts |
| title_full | Designer peptides to understand the mineralization of calcium salts |
| title_fullStr | Designer peptides to understand the mineralization of calcium salts |
| title_full_unstemmed | Designer peptides to understand the mineralization of calcium salts |
| title_short | Designer peptides to understand the mineralization of calcium salts |
| title_sort | designer peptides to understand the mineralization of calcium salts |
| topic | biomineralization calcium carbonate crystallization oligopeptides |
| url | http://hdl.handle.net/1721.1/3779 |
| work_keys_str_mv | AT ajikumarparayilkumaran designerpeptidestounderstandthemineralizationofcalciumsalts AT lakshminarayananrajamani designerpeptidestounderstandthemineralizationofcalciumsalts AT valiyaveettilsuresh designerpeptidestounderstandthemineralizationofcalciumsalts AT kinirmanjunatha designerpeptidestounderstandthemineralizationofcalciumsalts |