Self-Assembled Coatings for Controlling Biomolecular Adsorption on Surfaces
We have investigated a series of molecular and polymeric approaches for generating adherent thin films that impart anti-fouling characteristics to oxide surfaces. These films incorporate oligo- or poly(ethylene glycol) moieties that are expressed in high density in the near-surface region. In our mo...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | en_US |
| Published: |
2003
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| Online Access: | http://hdl.handle.net/1721.1/3791 |
| _version_ | 1826190912651264000 |
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| author | Seong, Jiehyun Lee, Seok-Won Jun, Shinae Choi, Hyun-Goo Laibinis, Paul E. |
| author_facet | Seong, Jiehyun Lee, Seok-Won Jun, Shinae Choi, Hyun-Goo Laibinis, Paul E. |
| author_sort | Seong, Jiehyun |
| collection | MIT |
| description | We have investigated a series of molecular and polymeric approaches for generating adherent thin films that impart anti-fouling characteristics to oxide surfaces. These films incorporate oligo- or poly(ethylene glycol) moieties that are expressed in high density in the near-surface region. In our molecular approach, oligo(ethylene glycol)-terminated n-alkyl-trichlorosilanes, RO(CH₂CH₂O)₃(CH₂)₁₁SiCl₃, have been designed so to spontaneously adsorb onto oxide surfaces and produce densely packed films. Another strategy uses a surface initiated polymerization to generate reactive anchored polymer chains that are then chemically modified to incorporate oligo(ethylene glycol) units. Lastly, a comb copolymer comprising a poly(acrylic acid) backbone and different grafting ratios of a linear poly(ethylene oxide-r-propylene oxide) chain has been prepared that adsorbs onto surfaces and forms a poly(ethylene glycol)-exposing film in single step. These surface coatings provide varying levels of protein and cellular resistance that can be related to molecular-scale elements of their surface structure. |
| first_indexed | 2024-09-23T08:47:12Z |
| format | Article |
| id | mit-1721.1/3791 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T08:47:12Z |
| publishDate | 2003 |
| record_format | dspace |
| spelling | mit-1721.1/37912019-04-10T07:33:51Z Self-Assembled Coatings for Controlling Biomolecular Adsorption on Surfaces Seong, Jiehyun Lee, Seok-Won Jun, Shinae Choi, Hyun-Goo Laibinis, Paul E. polymer coatings protein adsorption surface modification thin films We have investigated a series of molecular and polymeric approaches for generating adherent thin films that impart anti-fouling characteristics to oxide surfaces. These films incorporate oligo- or poly(ethylene glycol) moieties that are expressed in high density in the near-surface region. In our molecular approach, oligo(ethylene glycol)-terminated n-alkyl-trichlorosilanes, RO(CH₂CH₂O)₃(CH₂)₁₁SiCl₃, have been designed so to spontaneously adsorb onto oxide surfaces and produce densely packed films. Another strategy uses a surface initiated polymerization to generate reactive anchored polymer chains that are then chemically modified to incorporate oligo(ethylene glycol) units. Lastly, a comb copolymer comprising a poly(acrylic acid) backbone and different grafting ratios of a linear poly(ethylene oxide-r-propylene oxide) chain has been prepared that adsorbs onto surfaces and forms a poly(ethylene glycol)-exposing film in single step. These surface coatings provide varying levels of protein and cellular resistance that can be related to molecular-scale elements of their surface structure. Singapore-MIT Alliance (SMA) 2003-12-08T16:02:44Z 2003-12-08T16:02:44Z 2003-01 Article http://hdl.handle.net/1721.1/3791 en_US Molecular Engineering of Biological and Chemical Systems (MEBCS); 444006 bytes application/pdf application/pdf |
| spellingShingle | polymer coatings protein adsorption surface modification thin films Seong, Jiehyun Lee, Seok-Won Jun, Shinae Choi, Hyun-Goo Laibinis, Paul E. Self-Assembled Coatings for Controlling Biomolecular Adsorption on Surfaces |
| title | Self-Assembled Coatings for Controlling Biomolecular Adsorption on Surfaces |
| title_full | Self-Assembled Coatings for Controlling Biomolecular Adsorption on Surfaces |
| title_fullStr | Self-Assembled Coatings for Controlling Biomolecular Adsorption on Surfaces |
| title_full_unstemmed | Self-Assembled Coatings for Controlling Biomolecular Adsorption on Surfaces |
| title_short | Self-Assembled Coatings for Controlling Biomolecular Adsorption on Surfaces |
| title_sort | self assembled coatings for controlling biomolecular adsorption on surfaces |
| topic | polymer coatings protein adsorption surface modification thin films |
| url | http://hdl.handle.net/1721.1/3791 |
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