Monitoring transient repolarization segment morphology deviations in mouse ECG
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2006.
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| Format: | Thesis |
| Language: | eng |
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Massachusetts Institute of Technology
2008
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| Online Access: | http://dspace.mit.edu/handle/1721.1/38304 http://hdl.handle.net/1721.1/38304 |
| _version_ | 1826191891216990208 |
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| author | Oefinger, Matthew Blake, 1976- |
| author2 | Roger C. Mark. |
| author_facet | Roger C. Mark. Oefinger, Matthew Blake, 1976- |
| author_sort | Oefinger, Matthew Blake, 1976- |
| collection | MIT |
| description | Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2006. |
| first_indexed | 2024-09-23T09:02:55Z |
| format | Thesis |
| id | mit-1721.1/38304 |
| institution | Massachusetts Institute of Technology |
| language | eng |
| last_indexed | 2024-09-23T09:02:55Z |
| publishDate | 2008 |
| publisher | Massachusetts Institute of Technology |
| record_format | dspace |
| spelling | mit-1721.1/383042019-04-10T20:25:18Z Monitoring transient repolarization segment morphology deviations in mouse ECG Oefinger, Matthew Blake, 1976- Roger C. Mark. Massachusetts Institute of Technology. Dept. of Electrical Engineering and Computer Science. Massachusetts Institute of Technology. Dept. of Electrical Engineering and Computer Science. Electrical Engineering and Computer Science. Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2006. Includes bibliographical references (p. 273-276). This thesis details the design, implementation and validation of a system that facilitates partial automation for detection of anomalous repolarization segment morphologies in the ECG of mice. The technology consists of hardware for signal conditioning of the electrocardiogram (ECG); software for the collection, archiving and real-time & retrospective Internet visualization of data; and an algorithm for morphology analysis of the repolarization segment in murine ECG. The system was validated using genetically engineered mouse subjects with elevated VLDL, analogous to LDL or "bad cholesterol" in humans, and elevated but modified HDL, or "good cholesterol." These subjects, so-called "double-knockout" or dKO mice, exhibit repolarization segment morphologies that are manifestations of severe cardiovascular pathophysiology. This thesis describes the technology in detail and its application to elucidating long-term trends in repolarization morphology deviations in dKO mice. The paper concludes with future work that will utilize the technology and potential clinical applications. by Matthew Blake Oefinger Ph.D. 2008-02-12T16:47:19Z 2008-02-12T16:47:19Z 2006 2006 Thesis http://dspace.mit.edu/handle/1721.1/38304 http://hdl.handle.net/1721.1/38304 153943344 eng M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. http://dspace.mit.edu/handle/1721.1/38304 http://dspace.mit.edu/handle/1721.1/7582 276 p. application/pdf Massachusetts Institute of Technology |
| spellingShingle | Electrical Engineering and Computer Science. Oefinger, Matthew Blake, 1976- Monitoring transient repolarization segment morphology deviations in mouse ECG |
| title | Monitoring transient repolarization segment morphology deviations in mouse ECG |
| title_full | Monitoring transient repolarization segment morphology deviations in mouse ECG |
| title_fullStr | Monitoring transient repolarization segment morphology deviations in mouse ECG |
| title_full_unstemmed | Monitoring transient repolarization segment morphology deviations in mouse ECG |
| title_short | Monitoring transient repolarization segment morphology deviations in mouse ECG |
| title_sort | monitoring transient repolarization segment morphology deviations in mouse ecg |
| topic | Electrical Engineering and Computer Science. |
| url | http://dspace.mit.edu/handle/1721.1/38304 http://hdl.handle.net/1721.1/38304 |
| work_keys_str_mv | AT oefingermatthewblake1976 monitoringtransientrepolarizationsegmentmorphologydeviationsinmouseecg |