Mathematical and mechanical modeling of vaso-occlusion in sickle cell disease
Thesis (S.M.)--Harvard-MIT Division of Health Sciences and Technology, 2007.
| প্রধান লেখক: | |
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| অন্যান্য লেখক: | |
| বিন্যাস: | গবেষণাপত্র |
| ভাষা: | eng |
| প্রকাশিত: |
Massachusetts Institute of Technology
2007
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| বিষয়গুলি: | |
| অনলাইন ব্যবহার করুন: | http://hdl.handle.net/1721.1/38660 |
| _version_ | 1826193089832681472 |
|---|---|
| author | Higgins, John M. (John Matthew) |
| author2 | L. Mahadevan. |
| author_facet | L. Mahadevan. Higgins, John M. (John Matthew) |
| author_sort | Higgins, John M. (John Matthew) |
| collection | MIT |
| description | Thesis (S.M.)--Harvard-MIT Division of Health Sciences and Technology, 2007. |
| first_indexed | 2024-09-23T09:33:54Z |
| format | Thesis |
| id | mit-1721.1/38660 |
| institution | Massachusetts Institute of Technology |
| language | eng |
| last_indexed | 2024-09-23T09:33:54Z |
| publishDate | 2007 |
| publisher | Massachusetts Institute of Technology |
| record_format | dspace |
| spelling | mit-1721.1/386602019-04-10T18:17:28Z Mathematical and mechanical modeling of vaso-occlusion in sickle cell disease Higgins, John M. (John Matthew) L. Mahadevan. Harvard University--MIT Division of Health Sciences and Technology. Harvard University--MIT Division of Health Sciences and Technology. Harvard University--MIT Division of Health Sciences and Technology. Thesis (S.M.)--Harvard-MIT Division of Health Sciences and Technology, 2007. Includes bibliographical references. Vaso-occlusive crises cause most of the morbidity and mortality associated with sickle cell disease. The proximal causes of these occlusive events are not well understood. The risks and consequences of vaso-occlusion however are clear. Ten percent of sickle cell disease patients will have a stroke by the age of 20. Two thirds of sickle cell disease patients require more than one hospitalization per year for treatment of pain crises. The flow behavior of blood samples from sickle cell patients was studied in an artificial microfluidic environment. This microfluidic environment allowed modulation of the hydrostatic pressure causing flow, the ambient oxygen concentration, and the vascular channel geometry. A range of blood samples was evaluated by selecting specimens with various hematocrits and concentrations of sickle hemoglobin. Velocity profiles were calculated following sudden changes in oxygen concentration. From these profiles, it was possible to create a phase space of vaso-occlusion in the artificial microfluidic environment. This phase space characterizes the environmental conditions in which sickle cell blood will stop flowing within a given interval of time. (cont.) This work is a first step in characterizing the inter-relationships between some of the control parameters governing vaso-occlusion: pressure, oxygen concentration, channel size, hematocrit, and sickle hemoglobin concentration. This artificial device enables a quantification of the effect of a clinical therapy, red blood cell exchange, as performed on an actual sickle cell patient. Additionally, three sample small molecules known to alter rates of sickle hemoglobin polymerization were evaluated for their ability to perturb the tendency of sickle cell blood to stop flowing. These results suggest a possible application of this technique to the diagnosis and monitoring of sickle cell patients as well as to the investigation of new regimens of existing treatments and altogether novel therapies. by John M. Higgins. S.M. 2007-08-29T20:41:00Z 2007-08-29T20:41:00Z 2007 2007 Thesis http://hdl.handle.net/1721.1/38660 163221930 eng M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. http://dspace.mit.edu/handle/1721.1/7582 36 leaves application/pdf Massachusetts Institute of Technology |
| spellingShingle | Harvard University--MIT Division of Health Sciences and Technology. Higgins, John M. (John Matthew) Mathematical and mechanical modeling of vaso-occlusion in sickle cell disease |
| title | Mathematical and mechanical modeling of vaso-occlusion in sickle cell disease |
| title_full | Mathematical and mechanical modeling of vaso-occlusion in sickle cell disease |
| title_fullStr | Mathematical and mechanical modeling of vaso-occlusion in sickle cell disease |
| title_full_unstemmed | Mathematical and mechanical modeling of vaso-occlusion in sickle cell disease |
| title_short | Mathematical and mechanical modeling of vaso-occlusion in sickle cell disease |
| title_sort | mathematical and mechanical modeling of vaso occlusion in sickle cell disease |
| topic | Harvard University--MIT Division of Health Sciences and Technology. |
| url | http://hdl.handle.net/1721.1/38660 |
| work_keys_str_mv | AT higginsjohnmjohnmatthew mathematicalandmechanicalmodelingofvasoocclusioninsicklecelldisease |