Computational approaches for the design and prediction of protein-protein interactions
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2007.
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| Format: | Thesis |
| Language: | eng |
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Massachusetts Institute of Technology
2007
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| Online Access: | http://hdl.handle.net/1721.1/38997 |
| _version_ | 1826216231702626304 |
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| author | Grigoryan, Gevorg, Ph. D. Massachusetts Institute of Technology |
| author2 | Amy E. Keating. |
| author_facet | Amy E. Keating. Grigoryan, Gevorg, Ph. D. Massachusetts Institute of Technology |
| author_sort | Grigoryan, Gevorg, Ph. D. Massachusetts Institute of Technology |
| collection | MIT |
| description | Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2007. |
| first_indexed | 2024-09-23T16:44:24Z |
| format | Thesis |
| id | mit-1721.1/38997 |
| institution | Massachusetts Institute of Technology |
| language | eng |
| last_indexed | 2024-09-23T16:44:24Z |
| publishDate | 2007 |
| publisher | Massachusetts Institute of Technology |
| record_format | dspace |
| spelling | mit-1721.1/389972019-04-12T15:47:59Z Computational approaches for the design and prediction of protein-protein interactions Grigoryan, Gevorg, Ph. D. Massachusetts Institute of Technology Amy E. Keating. Massachusetts Institute of Technology. Dept. of Biology. Massachusetts Institute of Technology. Dept. of Biology. Biology. Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2007. Includes bibliographical references (leaves 167-187). There is a large class of applications in computational structural biology for which atomic-level representation is crucial for understanding the underlying biological phenomena, yet explicit atomic-level modeling is computationally prohibitive. Computational protein design, homology modeling, protein interaction prediction, docking and structure recognition are among these applications. Models that are commonly applied to these problems combine atomic-level representation with assumptions and approximations that make them computationally feasible. In this thesis I focus on several aspects of this type of modeling, analyze its limitations, propose improvements and explore applications to the design and prediction of protein-protein interactions. by Gevorg Grigoryan. Ph.D. 2007-09-28T13:29:45Z 2007-09-28T13:29:45Z 2007 2007 Thesis http://hdl.handle.net/1721.1/38997 166428687 eng M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. http://dspace.mit.edu/handle/1721.1/7582 187 leaves application/pdf Massachusetts Institute of Technology |
| spellingShingle | Biology. Grigoryan, Gevorg, Ph. D. Massachusetts Institute of Technology Computational approaches for the design and prediction of protein-protein interactions |
| title | Computational approaches for the design and prediction of protein-protein interactions |
| title_full | Computational approaches for the design and prediction of protein-protein interactions |
| title_fullStr | Computational approaches for the design and prediction of protein-protein interactions |
| title_full_unstemmed | Computational approaches for the design and prediction of protein-protein interactions |
| title_short | Computational approaches for the design and prediction of protein-protein interactions |
| title_sort | computational approaches for the design and prediction of protein protein interactions |
| topic | Biology. |
| url | http://hdl.handle.net/1721.1/38997 |
| work_keys_str_mv | AT grigoryangevorgphdmassachusettsinstituteoftechnology computationalapproachesforthedesignandpredictionofproteinproteininteractions |