Nanoparticles for Targeted Drug Delivery
Nanoparticles were synthesized and modified for target drug delivery. The research involved the aqueous synthesis of near infrared (NIR) sensitive Au-Au<sub>2</sub>S nanoparticles. An anti-cancer drug (<i>cis-platin</i>) was subsequently adsorbed onto the Au-Au<sub>2<...
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| Format: | Article |
| Language: | en_US |
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2003
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| Online Access: | http://hdl.handle.net/1721.1/3936 |
| _version_ | 1826217813761589248 |
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| author | Chow, Gan-Moog |
| author_facet | Chow, Gan-Moog |
| author_sort | Chow, Gan-Moog |
| collection | MIT |
| description | Nanoparticles were synthesized and modified for target drug delivery. The research involved the aqueous synthesis of near infrared (NIR) sensitive Au-Au<sub>2</sub>S nanoparticles. An anti-cancer drug (<i>cis-platin</i>) was subsequently adsorbed onto the Au-Au<sub>2</sub>S nanoparticle surface via the 11-mercaptoundecanoic acid layers. The results showed that the degree of adsorption of cis-platin onto Au-Au<sub>2</sub>S nanoparticles was controlled by the pH value of solution, and the rate of drug release was sensitive to NIR irradiation. The results of the synthesis, drug-release properties and nanoparticle-cell interactions will be discussed. |
| first_indexed | 2024-09-23T17:09:34Z |
| format | Article |
| id | mit-1721.1/3936 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T17:09:34Z |
| publishDate | 2003 |
| record_format | dspace |
| spelling | mit-1721.1/39362019-04-11T08:18:40Z Nanoparticles for Targeted Drug Delivery Chow, Gan-Moog nanoparticles targeted drug delivery near infrared sensitive Au-Au<sub>2</sub>S nanoparticles anti-cancer drugs NIR irradiation adsorption of cis-platin Nanoparticles were synthesized and modified for target drug delivery. The research involved the aqueous synthesis of near infrared (NIR) sensitive Au-Au<sub>2</sub>S nanoparticles. An anti-cancer drug (<i>cis-platin</i>) was subsequently adsorbed onto the Au-Au<sub>2</sub>S nanoparticle surface via the 11-mercaptoundecanoic acid layers. The results showed that the degree of adsorption of cis-platin onto Au-Au<sub>2</sub>S nanoparticles was controlled by the pH value of solution, and the rate of drug release was sensitive to NIR irradiation. The results of the synthesis, drug-release properties and nanoparticle-cell interactions will be discussed. Singapore-MIT Alliance (SMA) 2003-12-16T14:00:17Z 2003-12-16T14:00:17Z 2004-01 Article http://hdl.handle.net/1721.1/3936 en_US Molecular Engineering of Biological and Chemical Systems (MEBCS); 12186 bytes application/pdf application/pdf |
| spellingShingle | nanoparticles targeted drug delivery near infrared sensitive Au-Au<sub>2</sub>S nanoparticles anti-cancer drugs NIR irradiation adsorption of cis-platin Chow, Gan-Moog Nanoparticles for Targeted Drug Delivery |
| title | Nanoparticles for Targeted Drug Delivery |
| title_full | Nanoparticles for Targeted Drug Delivery |
| title_fullStr | Nanoparticles for Targeted Drug Delivery |
| title_full_unstemmed | Nanoparticles for Targeted Drug Delivery |
| title_short | Nanoparticles for Targeted Drug Delivery |
| title_sort | nanoparticles for targeted drug delivery |
| topic | nanoparticles targeted drug delivery near infrared sensitive Au-Au<sub>2</sub>S nanoparticles anti-cancer drugs NIR irradiation adsorption of cis-platin |
| url | http://hdl.handle.net/1721.1/3936 |
| work_keys_str_mv | AT chowganmoog nanoparticlesfortargeteddrugdelivery |