Modeling and simulating human cardiovascular response to acceleration
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2007.
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| Format: | Thesis |
| Language: | eng |
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Massachusetts Institute of Technology
2008
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| Online Access: | http://hdl.handle.net/1721.1/40536 |
| _version_ | 1811096243326156800 |
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| author | Zamanian, Sam Ahmad |
| author2 | George C. Verghese and Thomas Heldt. |
| author_facet | George C. Verghese and Thomas Heldt. Zamanian, Sam Ahmad |
| author_sort | Zamanian, Sam Ahmad |
| collection | MIT |
| description | Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2007. |
| first_indexed | 2024-09-23T16:40:51Z |
| format | Thesis |
| id | mit-1721.1/40536 |
| institution | Massachusetts Institute of Technology |
| language | eng |
| last_indexed | 2024-09-23T16:40:51Z |
| publishDate | 2008 |
| publisher | Massachusetts Institute of Technology |
| record_format | dspace |
| spelling | mit-1721.1/405362019-04-10T07:48:05Z Modeling and simulating human cardiovascular response to acceleration Zamanian, Sam Ahmad George C. Verghese and Thomas Heldt. Massachusetts Institute of Technology. Dept. of Electrical Engineering and Computer Science. Massachusetts Institute of Technology. Dept. of Electrical Engineering and Computer Science. Electrical Engineering and Computer Science. Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2007. Includes bibliographical references (p. 95-98). The human cardiovascular system routinely encounters conditions that cause it to adapt. For example, when an astronaut enters microgravity, his/her cardiovascular system adapts rapidly to the weightless environment with no functional impairment. This adaptation is entirely appropriate while in space. However, it predisposes astronauts to problems when they return. It has been suggested that the regimen for astronauts on long-duration space travel include periods of artificial acceleration via centrifugation, in order to maintain some exposure to a gravitational gradient and thus ameliorate some of the physiological consequences of exposure to microgravity. To design such an intervention, it is desirable to know and understand, as well as to predict the cardiovascular response to centrifugation stress. A reasonably compartmentalized mathematical model of the cardiovascular system that represents these conditions is presented, which will allow for understanding and predicting cardiovascular behavior under such conditions. We validated our simulations against human data and showed that our results closely matched the experimental data. Upon validation, we used our model to predict the response of the cardiovascular system to levels of stress that cannot yet be tested on human subjects. by Sam Ahmad Zamanian. S.M. 2008-02-27T22:44:45Z 2008-02-27T22:44:45Z 2007 2007 Thesis http://hdl.handle.net/1721.1/40536 192001785 eng M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. http://dspace.mit.edu/handle/1721.1/7582 98 p. application/pdf Massachusetts Institute of Technology |
| spellingShingle | Electrical Engineering and Computer Science. Zamanian, Sam Ahmad Modeling and simulating human cardiovascular response to acceleration |
| title | Modeling and simulating human cardiovascular response to acceleration |
| title_full | Modeling and simulating human cardiovascular response to acceleration |
| title_fullStr | Modeling and simulating human cardiovascular response to acceleration |
| title_full_unstemmed | Modeling and simulating human cardiovascular response to acceleration |
| title_short | Modeling and simulating human cardiovascular response to acceleration |
| title_sort | modeling and simulating human cardiovascular response to acceleration |
| topic | Electrical Engineering and Computer Science. |
| url | http://hdl.handle.net/1721.1/40536 |
| work_keys_str_mv | AT zamaniansamahmad modelingandsimulatinghumancardiovascularresponsetoacceleration |