Evaluation of nanoparticles-based thermotherapy for cancer
Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 2007.
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| Format: | Thesis |
| Language: | eng |
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Massachusetts Institute of Technology
2008
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| Online Access: | http://hdl.handle.net/1721.1/42152 |
| _version_ | 1826215210299424768 |
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| author | Wiryaatmadja, Edwina |
| author2 | Caroline Anne Ross. |
| author_facet | Caroline Anne Ross. Wiryaatmadja, Edwina |
| author_sort | Wiryaatmadja, Edwina |
| collection | MIT |
| description | Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 2007. |
| first_indexed | 2024-09-23T16:19:06Z |
| format | Thesis |
| id | mit-1721.1/42152 |
| institution | Massachusetts Institute of Technology |
| language | eng |
| last_indexed | 2024-09-23T16:19:06Z |
| publishDate | 2008 |
| publisher | Massachusetts Institute of Technology |
| record_format | dspace |
| spelling | mit-1721.1/421522019-04-10T22:36:54Z Evaluation of nanoparticles-based thermotherapy for cancer Wiryaatmadja, Edwina Caroline Anne Ross. Massachusetts Institute of Technology. Dept. of Materials Science and Engineering. Massachusetts Institute of Technology. Dept. of Materials Science and Engineering. Materials Science and Engineering. Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 2007. Includes bibliographical references (p. 83-88). Under alternating magnetic field, superparamagnetic iron oxide nanoparticles can be used to generate heat for the treatment of cancer. With suitable coating, these nanoparticles are biocompatible, stable in solution, and absorbed by tumor cells in good contrast. The mechanism of heating is mainly due to Neel relaxation process and a quantity called specific loss power (SLP) / specific absorption rate (SAR) is used to describe the heating effect. Past clinical studies have shown minimum side effects and proven the success of the new thermotherapy as a treatment modality in conjunction with chemo- or radiotherapy. Studies are in progress to improve the nanoparticles' heating power to enable treatment of small tumors and metastases, thermoablation as a monotherapy, and to achieve tumor-specific thermotherapy with the aid of tumor-finding molecules. This paper evaluates the novel technology that is magnetic nanoparticles-based thermotherapy and explores its commercialization potential. It explains the medical need driving the innovation, examines the technology in comparison with existing cancer therapies, identifies the strategic position the technology has in the present state of market for cancer therapies, and explores opportunities and Challenges in the introduction of the new therapy into the U.S. market. by Edwina Wiryaatmadja. M.Eng. 2008-09-03T14:44:21Z 2008-09-03T14:44:21Z 2007 2007 Thesis http://hdl.handle.net/1721.1/42152 228417099 eng M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. http://dspace.mit.edu/handle/1721.1/7582 88 p. application/pdf Massachusetts Institute of Technology |
| spellingShingle | Materials Science and Engineering. Wiryaatmadja, Edwina Evaluation of nanoparticles-based thermotherapy for cancer |
| title | Evaluation of nanoparticles-based thermotherapy for cancer |
| title_full | Evaluation of nanoparticles-based thermotherapy for cancer |
| title_fullStr | Evaluation of nanoparticles-based thermotherapy for cancer |
| title_full_unstemmed | Evaluation of nanoparticles-based thermotherapy for cancer |
| title_short | Evaluation of nanoparticles-based thermotherapy for cancer |
| title_sort | evaluation of nanoparticles based thermotherapy for cancer |
| topic | Materials Science and Engineering. |
| url | http://hdl.handle.net/1721.1/42152 |
| work_keys_str_mv | AT wiryaatmadjaedwina evaluationofnanoparticlesbasedthermotherapyforcancer |