Extending imaging depth of multiphoton microscopy
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2007.
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| Format: | Thesis |
| Language: | eng |
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Massachusetts Institute of Technology
2008
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| Online Access: | http://hdl.handle.net/1721.1/42299 |
| _version_ | 1826191281988042752 |
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| author | Cha, Jae Won |
| author2 | Peter T.C. So. |
| author_facet | Peter T.C. So. Cha, Jae Won |
| author_sort | Cha, Jae Won |
| collection | MIT |
| description | Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2007. |
| first_indexed | 2024-09-23T08:53:48Z |
| format | Thesis |
| id | mit-1721.1/42299 |
| institution | Massachusetts Institute of Technology |
| language | eng |
| last_indexed | 2024-09-23T08:53:48Z |
| publishDate | 2008 |
| publisher | Massachusetts Institute of Technology |
| record_format | dspace |
| spelling | mit-1721.1/422992019-04-10T19:36:15Z Extending imaging depth of multiphoton microscopy Cha, Jae Won Peter T.C. So. Massachusetts Institute of Technology. Dept. of Mechanical Engineering. Massachusetts Institute of Technology. Dept. of Mechanical Engineering. Mechanical Engineering. Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2007. Includes bibliographical references (leaves 45-46). Two-photon excitation fluorescence microscopy has capability of deep tissue imaging with biological samples. However, because of the inhomogeneity of the refractive index in biological samples, the wavefront of the excitation light is often distorted. Due to the distortion of the wavefront, the point spread function at the focal point becomes broadened resulting in degraded resolution and lower signal. With an adaptive optics system, which consists of a wavefront camera and deformable mirror, the wavefront distortion can be measured and corrected. By correcting the distorted wavefront with adaptive optics, resolution and signal level can be preserved at greater imaging depth. by Jae Won Cha. S.M. 2008-09-03T15:16:14Z 2008-09-03T15:16:14Z 2007 2007 Thesis http://hdl.handle.net/1721.1/42299 232359016 eng M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. http://dspace.mit.edu/handle/1721.1/7582 49 leaves application/pdf Massachusetts Institute of Technology |
| spellingShingle | Mechanical Engineering. Cha, Jae Won Extending imaging depth of multiphoton microscopy |
| title | Extending imaging depth of multiphoton microscopy |
| title_full | Extending imaging depth of multiphoton microscopy |
| title_fullStr | Extending imaging depth of multiphoton microscopy |
| title_full_unstemmed | Extending imaging depth of multiphoton microscopy |
| title_short | Extending imaging depth of multiphoton microscopy |
| title_sort | extending imaging depth of multiphoton microscopy |
| topic | Mechanical Engineering. |
| url | http://hdl.handle.net/1721.1/42299 |
| work_keys_str_mv | AT chajaewon extendingimagingdepthofmultiphotonmicroscopy |