Reservoir-based devices for the monitoring and treatment of disease
Thesis (Ph. D.)--Harvard-MIT Division of Health Sciences and Technology, 2008.
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| Format: | Thesis |
| Language: | eng |
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Massachusetts Institute of Technology
2008
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| Online Access: | http://hdl.handle.net/1721.1/43806 |
| _version_ | 1811089211018706944 |
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| author | Kim, Grace Young |
| author2 | Michael J. Cima. |
| author_facet | Michael J. Cima. Kim, Grace Young |
| author_sort | Kim, Grace Young |
| collection | MIT |
| description | Thesis (Ph. D.)--Harvard-MIT Division of Health Sciences and Technology, 2008. |
| first_indexed | 2024-09-23T14:15:35Z |
| format | Thesis |
| id | mit-1721.1/43806 |
| institution | Massachusetts Institute of Technology |
| language | eng |
| last_indexed | 2024-09-23T14:15:35Z |
| publishDate | 2008 |
| publisher | Massachusetts Institute of Technology |
| record_format | dspace |
| spelling | mit-1721.1/438062019-04-10T16:25:49Z Reservoir-based devices for the monitoring and treatment of disease Kim, Grace Young Michael J. Cima. Harvard University--MIT Division of Health Sciences and Technology. Harvard University--MIT Division of Health Sciences and Technology. Harvard University--MIT Division of Health Sciences and Technology. Thesis (Ph. D.)--Harvard-MIT Division of Health Sciences and Technology, 2008. Includes bibliographical references. Cancer mortality still remains high despite significant investments in diagnostics, drug development, and treatment. The systemic route is convenient both for routine monitoring and for drug administration. Local cancer biomarker concentrations, however, are more indicative of the state of solid tumors and their response to therapy. Furthermore, local drug delivery can achieve efficacy where systemic treatments fail. This dissertation describes two reservoir-based devices to enable such local approaches. We are applying superparamagnetic crosslinked iron oxide nanoparticles (CLIO) for the quantitative measurements of soluble cancer biomarkers. These nanoparticles are functionalized to react specifically in the presence of their target analyte. An implanted device with a size-exclusion membrane was used to contain the CLIO and to expose them to the cancer milieu. The system was designed to be deployed deep within the body and indirectly detect cancer cells and their activity by their secreted products, which are produced at a very high copy number by each cell. A reservoir-based polymeric device has also been applied for local chemotherapy. A biodegradable polymer microchip was designed in our group to independently deliver more than one therapeutic agent. Only in vitro release of active compounds had been previously demonstrated. The work in this thesis achieves local drug therapy from the polymer microchip and demonstrates efficacy against an in vivo tumor model of brain cancer. The reservoir-based device approach has the potential to enable early detection of cancer recurrence, personalized drug treatments, and localized multi-drug therapy. by Grace Young Kim. Ph.D. 2008-12-11T18:30:46Z 2008-12-11T18:30:46Z 2008 2008 Thesis http://hdl.handle.net/1721.1/43806 261525469 eng M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. http://dspace.mit.edu/handle/1721.1/7582 151 p. application/pdf Massachusetts Institute of Technology |
| spellingShingle | Harvard University--MIT Division of Health Sciences and Technology. Kim, Grace Young Reservoir-based devices for the monitoring and treatment of disease |
| title | Reservoir-based devices for the monitoring and treatment of disease |
| title_full | Reservoir-based devices for the monitoring and treatment of disease |
| title_fullStr | Reservoir-based devices for the monitoring and treatment of disease |
| title_full_unstemmed | Reservoir-based devices for the monitoring and treatment of disease |
| title_short | Reservoir-based devices for the monitoring and treatment of disease |
| title_sort | reservoir based devices for the monitoring and treatment of disease |
| topic | Harvard University--MIT Division of Health Sciences and Technology. |
| url | http://hdl.handle.net/1721.1/43806 |
| work_keys_str_mv | AT kimgraceyoung reservoirbaseddevicesforthemonitoringandtreatmentofdisease |