DNA as a programmable material : de novo gene synthesis and error correction
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 2008.
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| Other Authors: | |
| Format: | Thesis |
| Language: | eng |
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Massachusetts Institute of Technology
2009
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| Online Access: | http://hdl.handle.net/1721.1/44423 |
| _version_ | 1826191324161769472 |
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| author | Hwang, Samuel James |
| author2 | Joseph Jacobson. |
| author_facet | Joseph Jacobson. Hwang, Samuel James |
| author_sort | Hwang, Samuel James |
| collection | MIT |
| description | Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 2008. |
| first_indexed | 2024-09-23T08:54:07Z |
| format | Thesis |
| id | mit-1721.1/44423 |
| institution | Massachusetts Institute of Technology |
| language | eng |
| last_indexed | 2024-09-23T08:54:07Z |
| publishDate | 2009 |
| publisher | Massachusetts Institute of Technology |
| record_format | dspace |
| spelling | mit-1721.1/444232019-04-10T19:38:00Z DNA as a programmable material : de novo gene synthesis and error correction Deoxyribonucleic acid as a programmable material Hwang, Samuel James Joseph Jacobson. Massachusetts Institute of Technology. Dept. of Materials Science and Engineering. Massachusetts Institute of Technology. Dept. of Materials Science and Engineering. Materials Science and Engineering. Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 2008. Includes bibliographical references (leaves 42-43). Deoxyribonucleic acid (DNA), the polymeric molecule that carries the genetic code of all living organisms, is arguably one of the most programmable assembly materials available to chemists, biologists, and materials scientists. Scientists have used DNA to build many different structures for various applications in disparate areas of research from traditional biological applications to more recent non-biological applications. Although DNA isn't typically thought of as an assembly material by people not doing research in the area, the availability of decreasing cost synthetic oligonucleotides has led to advances in gene fabrication technology which in turn has enabled synthetic biology to flourish. Using DNA as a building material for small and large constructs of DNA is reliant on having effective gene synthesis techniques. Construction of synthetic DNA is limited by errors that pervade the final product. To address this problem, effective error correction methods are pivotal. Having extremely robust gene synthesis and error correction techniques will allow researchers to generate very large scale constructs potentially necessary in applications such as genome re-engineering. by Samuel James Hwang. S.M. 2009-01-30T16:45:02Z 2009-01-30T16:45:02Z 2008 2008 Thesis http://hdl.handle.net/1721.1/44423 289478664 eng M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. http://dspace.mit.edu/handle/1721.1/7582 43 leaves application/pdf Massachusetts Institute of Technology |
| spellingShingle | Materials Science and Engineering. Hwang, Samuel James DNA as a programmable material : de novo gene synthesis and error correction |
| title | DNA as a programmable material : de novo gene synthesis and error correction |
| title_full | DNA as a programmable material : de novo gene synthesis and error correction |
| title_fullStr | DNA as a programmable material : de novo gene synthesis and error correction |
| title_full_unstemmed | DNA as a programmable material : de novo gene synthesis and error correction |
| title_short | DNA as a programmable material : de novo gene synthesis and error correction |
| title_sort | dna as a programmable material de novo gene synthesis and error correction |
| topic | Materials Science and Engineering. |
| url | http://hdl.handle.net/1721.1/44423 |
| work_keys_str_mv | AT hwangsamueljames dnaasaprogrammablematerialdenovogenesynthesisanderrorcorrection AT hwangsamueljames deoxyribonucleicacidasaprogrammablematerial |