Financial viability and technical evaluation of dendritic cell-carrying "vaccination nodes" for immunotherapy
Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 2008.
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| Format: | Thesis |
| Language: | eng |
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Massachusetts Institute of Technology
2009
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| Online Access: | http://hdl.handle.net/1721.1/45353 |
| _version_ | 1811071222846324736 |
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| author | Song, Andrew, M. Eng. Massachusetts Institute of Technology |
| author2 | Darrell J. Irvine. |
| author_facet | Darrell J. Irvine. Song, Andrew, M. Eng. Massachusetts Institute of Technology |
| author_sort | Song, Andrew, M. Eng. Massachusetts Institute of Technology |
| collection | MIT |
| description | Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 2008. |
| first_indexed | 2024-09-23T08:47:51Z |
| format | Thesis |
| id | mit-1721.1/45353 |
| institution | Massachusetts Institute of Technology |
| language | eng |
| last_indexed | 2024-09-23T08:47:51Z |
| publishDate | 2009 |
| publisher | Massachusetts Institute of Technology |
| record_format | dspace |
| spelling | mit-1721.1/453532019-04-10T07:36:49Z Financial viability and technical evaluation of dendritic cell-carrying "vaccination nodes" for immunotherapy Song, Andrew, M. Eng. Massachusetts Institute of Technology Darrell J. Irvine. Massachusetts Institute of Technology. Dept. of Materials Science and Engineering. Massachusetts Institute of Technology. Dept. of Materials Science and Engineering. Materials Science and Engineering. Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 2008. Includes bibliographical references (leaves 66-69). Cancer immunotherapy attempts to stimulate the immune system to reject and destroy tumor cells. Despite the amount of ongoing intensive research to prevent cancer, tumor cells continue to evade immune responses. Currently, dendritic cell vaccines are in development, in which autologous antigen-loaded dendritic cells are injected back into the patient in order to generate an appropriate immune response. Improving upon this idea, members of the Irvine laboratory are in development of an injectable dendritic cell based formulation that gels in situ around the tumor site. In this way, immune cells (most notably T cells) can be recruited and become activated against specific tumor antigens, and (hopefully) kill tumor cells. Recent studies have shown the potential benefit of incorporation of cytokine interleukin-15 complexed with its soluble receptor interleukin-5R[alpha], which is discussed. Economic considerations are also discussed, including topics such as intellectual property, barriers to entry, initial markets and market drivers, and entry into the current supply chain considerations. A business strategy is outlined and evaluated. by Andrew Song. M.Eng. 2009-04-29T17:29:34Z 2009-04-29T17:29:34Z 2008 2008 Thesis http://hdl.handle.net/1721.1/45353 316802186 eng M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. http://dspace.mit.edu/handle/1721.1/7582 69 leaves application/pdf Massachusetts Institute of Technology |
| spellingShingle | Materials Science and Engineering. Song, Andrew, M. Eng. Massachusetts Institute of Technology Financial viability and technical evaluation of dendritic cell-carrying "vaccination nodes" for immunotherapy |
| title | Financial viability and technical evaluation of dendritic cell-carrying "vaccination nodes" for immunotherapy |
| title_full | Financial viability and technical evaluation of dendritic cell-carrying "vaccination nodes" for immunotherapy |
| title_fullStr | Financial viability and technical evaluation of dendritic cell-carrying "vaccination nodes" for immunotherapy |
| title_full_unstemmed | Financial viability and technical evaluation of dendritic cell-carrying "vaccination nodes" for immunotherapy |
| title_short | Financial viability and technical evaluation of dendritic cell-carrying "vaccination nodes" for immunotherapy |
| title_sort | financial viability and technical evaluation of dendritic cell carrying vaccination nodes for immunotherapy |
| topic | Materials Science and Engineering. |
| url | http://hdl.handle.net/1721.1/45353 |
| work_keys_str_mv | AT songandrewmengmassachusettsinstituteoftechnology financialviabilityandtechnicalevaluationofdendriticcellcarryingvaccinationnodesforimmunotherapy |