Silencing and recombination in yeast ribosomal DNA
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Physics, 2008.
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| Format: | Thesis |
| Language: | eng |
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Massachusetts Institute of Technology
2009
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| Online Access: | http://hdl.handle.net/1721.1/45436 |
| _version_ | 1826210764151586816 |
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| author | O'Kelly, Michael J. T |
| author2 | Alexander van Oudenaarden. |
| author_facet | Alexander van Oudenaarden. O'Kelly, Michael J. T |
| author_sort | O'Kelly, Michael J. T |
| collection | MIT |
| description | Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Physics, 2008. |
| first_indexed | 2024-09-23T14:55:03Z |
| format | Thesis |
| id | mit-1721.1/45436 |
| institution | Massachusetts Institute of Technology |
| language | eng |
| last_indexed | 2024-09-23T14:55:03Z |
| publishDate | 2009 |
| publisher | Massachusetts Institute of Technology |
| record_format | dspace |
| spelling | mit-1721.1/454362019-04-12T21:29:56Z Silencing and recombination in yeast ribosomal DNA O'Kelly, Michael J. T Alexander van Oudenaarden. Massachusetts Institute of Technology. Dept. of Physics. Massachusetts Institute of Technology. Dept. of Physics. Physics. Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Physics, 2008. Includes bibliographical references (p. 129-132). A bioinformatic and laboratory investigation into S. cerevisiae's system for the maintenance and homogenization of rDNA. Eliminating mutations and heterogeneity in rDNA repeats is necessary evolutionarily, but harmful to individual organisms--and has been linked to aging-related pathology. We present a forensic investigation of this process using a new whole-genome shotgun dataset, and interpret the results in light of experimental results showing the dynamics of rDNA silencing and recombination in laboratory strains. by Michael J.T. O'Kelly. Ph.D. 2009-04-29T17:41:56Z 2009-04-29T17:41:56Z 2008 2008 Thesis http://hdl.handle.net/1721.1/45436 317950968 eng M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. http://dspace.mit.edu/handle/1721.1/7582 151 p. application/pdf Massachusetts Institute of Technology |
| spellingShingle | Physics. O'Kelly, Michael J. T Silencing and recombination in yeast ribosomal DNA |
| title | Silencing and recombination in yeast ribosomal DNA |
| title_full | Silencing and recombination in yeast ribosomal DNA |
| title_fullStr | Silencing and recombination in yeast ribosomal DNA |
| title_full_unstemmed | Silencing and recombination in yeast ribosomal DNA |
| title_short | Silencing and recombination in yeast ribosomal DNA |
| title_sort | silencing and recombination in yeast ribosomal dna |
| topic | Physics. |
| url | http://hdl.handle.net/1721.1/45436 |
| work_keys_str_mv | AT okellymichaeljt silencingandrecombinationinyeastribosomaldna |