Different gene regulation strategies revealed by analysis of binding motifs
Coordinated regulation of gene expression relies on transcription factors (TFs) binding to specific DNA sites. Our large-scale information-theoretic analysis of >950 TF-binding motifs demonstrates that prokaryotes and eukaryotes use strikingly different strategies to target TFs to specific genom...
Main Authors: | Mirny, Leonid A., Wunderlich, Zeba |
---|---|
Other Authors: | Harvard University--MIT Division of Health Sciences and Technology |
Format: | Article |
Language: | en_US |
Published: |
Elsevier Ltd.
2009
|
Online Access: | http://hdl.handle.net/1721.1/49486 https://orcid.org/0000-0002-0785-5410 |
Similar Items
-
Using genome-wide measurements for computational prediction of SH2–peptide interactions
by: Wunderlich, Zeba, et al.
Published: (2012) -
Spatial effects on the speed and reliability of protein–DNA search
by: Wunderlich, Zeba, et al.
Published: (2012) -
Using Topology of the Metabolic Network to Predict Viability of Mutant Strains
by: Mirny, Leonid A., et al.
Published: (2010) -
Motifs, binding, and expression : computational studies of transcriptional regulation
by: MacIsaac, Kenzie D. (Kenzie Daniel), 1975-
Published: (2010) -
High Resolution Genome Wide Binding Event Finding and Motif Discovery Reveals Transcription Factor Spatial Binding Constraints
by: Guo, Yuchun, et al.
Published: (2012)