Design of Specific Mammalian Promoters by in silico Prediction

The purpose of this RFC is to provide a) a method for the design of rational synthetic promoter sequences based on a statistical analysis about the spatial preference of transcription factor binding sites in human promoter sequences and b) further introduce standards to provide compatibility with...

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Bibliographic Details
Main Authors: Heinemann, Tim, Kramer, Stephen, Velten, Lars, Kranz, Anna-Lena, Bauer, Tobias, Faura, Marti Bernardo, Konig, Rainer, Keienburg, Jens, Eils, Roland, Iwamoto, Nao
Format: Technical Report
Published: 2009
Subjects:
Online Access:http://hdl.handle.net/1721.1/49520
Description
Summary:The purpose of this RFC is to provide a) a method for the design of rational synthetic promoter sequences based on a statistical analysis about the spatial preference of transcription factor binding sites in human promoter sequences and b) further introduce standards to provide compatibility with data formats introduced in this RFC. Description of promoters generated by this method can be found at http://2009.igem.org/Team:Heidelberg/HEARTBEAT_database.