Application of lean and continuous improvement methodologies at a biopharmaceutical manufacturing site

Thesis (M.B.A.)--Massachusetts Institute of Technology, Sloan School of Management; and, (S.M.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering; in conjunction with the Leaders for Manufacturing Program at MIT, 2009.

Bibliographic Details
Main Author: Jay, Wayne G. W
Other Authors: Roy E. Welsch and Charles Cooney.
Format: Thesis
Language:eng
Published: Massachusetts Institute of Technology 2009
Subjects:
Online Access:http://hdl.handle.net/1721.1/50087
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author Jay, Wayne G. W
author2 Roy E. Welsch and Charles Cooney.
author_facet Roy E. Welsch and Charles Cooney.
Jay, Wayne G. W
author_sort Jay, Wayne G. W
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description Thesis (M.B.A.)--Massachusetts Institute of Technology, Sloan School of Management; and, (S.M.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering; in conjunction with the Leaders for Manufacturing Program at MIT, 2009.
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spelling mit-1721.1/500872022-01-28T18:28:07Z Application of lean and continuous improvement methodologies at a biopharmaceutical manufacturing site Jay, Wayne G. W Roy E. Welsch and Charles Cooney. Leaders for Manufacturing Program. Leaders for Manufacturing Program at MIT Massachusetts Institute of Technology. Department of Chemical Engineering Sloan School of Management Sloan School of Management. Chemical Engineering. Leaders for Manufacturing Program. Thesis (M.B.A.)--Massachusetts Institute of Technology, Sloan School of Management; and, (S.M.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering; in conjunction with the Leaders for Manufacturing Program at MIT, 2009. Includes bibliographical references (p. 61-62). Heightened competitive pressures, changes in the regulatory atmosphere, and dropping research and development productivity have been plaguing the pharmaceutical and biotechnology industries. Amgen has felt the effects of these forces and launched a new effort to improve its operations via continuous improvement and Lean, ultimately reducing costs and improving productivity of operations. This thesis examines one example of a process improvement effort at Amgen's Fremont manufacturing facility. This project involved characterizing the cycle times of their buffer solution preparation processes, leading to targeted actions to both minimize variability in the process and to reduce the amount of time and effort to manufacture tanks of buffer solution. Tools and ideas from Lean and Six Sigma were applied and a prioritized action plan was presented to the company. This thesis also provides a broader examination of how such continuous improvement efforts can fit into the biotechnology industry with its idiosyncrasies. by Wayne G.W. Jay. S.M. M.B.A. 2009-12-10T19:10:33Z 2009-12-10T19:10:33Z 2009 2009 Thesis http://hdl.handle.net/1721.1/50087 458566429 eng M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. http://dspace.mit.edu/handle/1721.1/7582 62 p. application/pdf Massachusetts Institute of Technology
spellingShingle Sloan School of Management.
Chemical Engineering.
Leaders for Manufacturing Program.
Jay, Wayne G. W
Application of lean and continuous improvement methodologies at a biopharmaceutical manufacturing site
title Application of lean and continuous improvement methodologies at a biopharmaceutical manufacturing site
title_full Application of lean and continuous improvement methodologies at a biopharmaceutical manufacturing site
title_fullStr Application of lean and continuous improvement methodologies at a biopharmaceutical manufacturing site
title_full_unstemmed Application of lean and continuous improvement methodologies at a biopharmaceutical manufacturing site
title_short Application of lean and continuous improvement methodologies at a biopharmaceutical manufacturing site
title_sort application of lean and continuous improvement methodologies at a biopharmaceutical manufacturing site
topic Sloan School of Management.
Chemical Engineering.
Leaders for Manufacturing Program.
url http://hdl.handle.net/1721.1/50087
work_keys_str_mv AT jaywaynegw applicationofleanandcontinuousimprovementmethodologiesatabiopharmaceuticalmanufacturingsite