Phosphorylation of MeCP2 at Serine 80 regulates its chromatin association and neurological function
Mutations of MECP2 (Methyl-CpG Binding Protein 2) cause Rett syndrome. As a chromatin-associated multifunctional protein, how MeCP2 integrates external signals and regulates neuronal function remain unclear. Although neuronal activity-induced phosphorylation of MeCP2 at serine 421 (S421) has been re...
Main Authors: | Tao, Jifang, Hu, Keping, Chang, Qiang, Wu, Hao, Sherman, Nicholas E., Martinowich, Keri, Klose, Robert J., Schanen, Carolyn, Jaenisch, Rudolf, Wang, Weidong, Sun, Yi Eve |
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Other Authors: | Massachusetts Institute of Technology. Department of Biology |
Format: | Article |
Language: | en_US |
Published: |
National Academy of Sciences
2009
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Online Access: | http://hdl.handle.net/1721.1/50246 |
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