Thymic Selection of T-Cell Receptors as an Extreme Value Problem
T lymphocytes (T cells) orchestrate adaptive immune responses upon activation. T-cell activation requires sufficiently strong binding of T-cell receptors on their surface to short peptides (p) derived from foreign proteins, which are bound to major histocompatibility gene products (displayed on anti...
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| Format: | Article |
| Language: | en_US |
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American Physical Society
2010
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| Online Access: | http://hdl.handle.net/1721.1/51770 https://orcid.org/0000-0003-1268-9602 https://orcid.org/0000-0002-1112-5912 |
| _version_ | 1826206755575562240 |
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| author | Kardar, Mehran Chakraborty, Arup K. Shaknovich, Eugene I. Kosmrlj, Andrej |
| author2 | Massachusetts Institute of Technology. Department of Biological Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Biological Engineering Kardar, Mehran Chakraborty, Arup K. Shaknovich, Eugene I. Kosmrlj, Andrej |
| author_sort | Kardar, Mehran |
| collection | MIT |
| description | T lymphocytes (T cells) orchestrate adaptive immune responses upon activation. T-cell activation requires sufficiently strong binding of T-cell receptors on their surface to short peptides (p) derived from foreign proteins, which are bound to major histocompatibility gene products (displayed on antigen-presenting cells). A diverse and self-tolerant T-cell repertoire is selected in the thymus. We map thymic selection processes to an extreme value problem and provide an analytic expression for the amino acid compositions of selected T-cell receptors (which enable its recognition functions). |
| first_indexed | 2024-09-23T13:38:04Z |
| format | Article |
| id | mit-1721.1/51770 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T13:38:04Z |
| publishDate | 2010 |
| publisher | American Physical Society |
| record_format | dspace |
| spelling | mit-1721.1/517702022-10-01T16:10:11Z Thymic Selection of T-Cell Receptors as an Extreme Value Problem Kardar, Mehran Chakraborty, Arup K. Shaknovich, Eugene I. Kosmrlj, Andrej Massachusetts Institute of Technology. Department of Biological Engineering Massachusetts Institute of Technology. Department of Chemical Engineering Massachusetts Institute of Technology. Department of Chemistry Massachusetts Institute of Technology. Department of Physics Chakraborty, Arup K. Kosmrlj, Andrej Kardar, Mehran Chakraborty, Arup K. T lymphocytes (T cells) orchestrate adaptive immune responses upon activation. T-cell activation requires sufficiently strong binding of T-cell receptors on their surface to short peptides (p) derived from foreign proteins, which are bound to major histocompatibility gene products (displayed on antigen-presenting cells). A diverse and self-tolerant T-cell repertoire is selected in the thymus. We map thymic selection processes to an extreme value problem and provide an analytic expression for the amino acid compositions of selected T-cell receptors (which enable its recognition functions). National Institutes of Health 2010-02-17T16:31:24Z 2010-02-17T16:31:24Z 2009-08 2009-03 Article http://purl.org/eprint/type/JournalArticle 0031-9007 http://hdl.handle.net/1721.1/51770 Kosmrlj, Andrej et al. “Thymic Selection of T-Cell Receptors as an Extreme Value Problem.” Physical Review Letters 103.6 (2009): 068103. © 2009 The American Physical Society. https://orcid.org/0000-0003-1268-9602 https://orcid.org/0000-0002-1112-5912 en_US http://dx.doi.org/10.1103/PhysRevLett.103.068103 Physical Review Letters Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf American Physical Society APS |
| spellingShingle | Kardar, Mehran Chakraborty, Arup K. Shaknovich, Eugene I. Kosmrlj, Andrej Thymic Selection of T-Cell Receptors as an Extreme Value Problem |
| title | Thymic Selection of T-Cell Receptors as an Extreme Value Problem |
| title_full | Thymic Selection of T-Cell Receptors as an Extreme Value Problem |
| title_fullStr | Thymic Selection of T-Cell Receptors as an Extreme Value Problem |
| title_full_unstemmed | Thymic Selection of T-Cell Receptors as an Extreme Value Problem |
| title_short | Thymic Selection of T-Cell Receptors as an Extreme Value Problem |
| title_sort | thymic selection of t cell receptors as an extreme value problem |
| url | http://hdl.handle.net/1721.1/51770 https://orcid.org/0000-0003-1268-9602 https://orcid.org/0000-0002-1112-5912 |
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