Separation of Microscale Chiral Objects by Shear Flow
We show that plane parabolic flow in a microfluidic channel causes nonmotile, helically shaped bacteria to drift perpendicular to the shear plane. Net drift results from the preferential alignment of helices with streamlines, with a direction that depends on the chirality of the helix and the sign o...
| Main Authors: | , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
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American Physical Society
2010
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| Online Access: | http://hdl.handle.net/1721.1/51794 https://orcid.org/0000-0002-3199-0508 |
| _version_ | 1826189770378706944 |
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| author | Powers, Thomas R. Fu, Henry C. Stocker, Roman Marcos |
| author2 | Massachusetts Institute of Technology. Department of Civil and Environmental Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Civil and Environmental Engineering Powers, Thomas R. Fu, Henry C. Stocker, Roman Marcos |
| author_sort | Powers, Thomas R. |
| collection | MIT |
| description | We show that plane parabolic flow in a microfluidic channel causes nonmotile, helically shaped bacteria to drift perpendicular to the shear plane. Net drift results from the preferential alignment of helices with streamlines, with a direction that depends on the chirality of the helix and the sign of the shear rate. The drift is in good agreement with a model based on resistive force theory, and separation is efficient (>80%) and fast (<2 s). We estimate the effect of Brownian rotational diffusion on chiral separation and show how this method can be extended to separate chiral molecules. |
| first_indexed | 2024-09-23T08:21:17Z |
| format | Article |
| id | mit-1721.1/51794 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T08:21:17Z |
| publishDate | 2010 |
| publisher | American Physical Society |
| record_format | dspace |
| spelling | mit-1721.1/517942022-09-23T12:26:59Z Separation of Microscale Chiral Objects by Shear Flow Powers, Thomas R. Fu, Henry C. Stocker, Roman Marcos Massachusetts Institute of Technology. Department of Civil and Environmental Engineering Massachusetts Institute of Technology. Department of Mechanical Engineering Stocker, Roman Marcos Stocker, Roman We show that plane parabolic flow in a microfluidic channel causes nonmotile, helically shaped bacteria to drift perpendicular to the shear plane. Net drift results from the preferential alignment of helices with streamlines, with a direction that depends on the chirality of the helix and the sign of the shear rate. The drift is in good agreement with a model based on resistive force theory, and separation is efficient (>80%) and fast (<2 s). We estimate the effect of Brownian rotational diffusion on chiral separation and show how this method can be extended to separate chiral molecules. 2010-02-23T20:25:13Z 2010-02-23T20:25:13Z 2009-04 2008-10 Article http://purl.org/eprint/type/JournalArticle 0031-9007 http://hdl.handle.net/1721.1/51794 Marcos et al. “Separation of Microscale Chiral Objects by Shear Flow.” Physical Review Letters 102.15 (2009): 158103.© 2009 The American Physical Society. https://orcid.org/0000-0002-3199-0508 en_US http://dx.doi.org/10.1103/PhysRevLett.102.158103 Physical Review Letters Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf American Physical Society APS |
| spellingShingle | Powers, Thomas R. Fu, Henry C. Stocker, Roman Marcos Separation of Microscale Chiral Objects by Shear Flow |
| title | Separation of Microscale Chiral Objects by Shear Flow |
| title_full | Separation of Microscale Chiral Objects by Shear Flow |
| title_fullStr | Separation of Microscale Chiral Objects by Shear Flow |
| title_full_unstemmed | Separation of Microscale Chiral Objects by Shear Flow |
| title_short | Separation of Microscale Chiral Objects by Shear Flow |
| title_sort | separation of microscale chiral objects by shear flow |
| url | http://hdl.handle.net/1721.1/51794 https://orcid.org/0000-0002-3199-0508 |
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