Internal Friction and Nonequilibrium Unfolding of Polymeric Globules
The stretching response of a single collapsed homopolymer is studied using Brownian dynamic simulations. The irreversibly dissipated work is found to be dominated by internal friction effects below the collapse temperature, and the internal viscosity grows exponentially with the effective cohesive s...
| Main Authors: | , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
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American Physical Society
2010
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| Online Access: | http://hdl.handle.net/1721.1/51824 https://orcid.org/0000-0001-5554-1283 |
| _version_ | 1811070271028723712 |
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| author | Wada, Hirofumi Netz, Roland R. Alexander-Katz, Alfredo |
| author2 | Massachusetts Institute of Technology. Department of Materials Science and Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Materials Science and Engineering Wada, Hirofumi Netz, Roland R. Alexander-Katz, Alfredo |
| author_sort | Wada, Hirofumi |
| collection | MIT |
| description | The stretching response of a single collapsed homopolymer is studied using Brownian dynamic simulations. The irreversibly dissipated work is found to be dominated by internal friction effects below the collapse temperature, and the internal viscosity grows exponentially with the effective cohesive strength between monomers. These results explain friction effects of globular DNA and are relevant for dissipation at intermediate stages of protein folding. |
| first_indexed | 2024-09-23T08:33:49Z |
| format | Article |
| id | mit-1721.1/51824 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T08:33:49Z |
| publishDate | 2010 |
| publisher | American Physical Society |
| record_format | dspace |
| spelling | mit-1721.1/518242022-09-30T09:35:58Z Internal Friction and Nonequilibrium Unfolding of Polymeric Globules Wada, Hirofumi Netz, Roland R. Alexander-Katz, Alfredo Massachusetts Institute of Technology. Department of Materials Science and Engineering Alexander-Katz, Alfredo Alexander-Katz, Alfredo The stretching response of a single collapsed homopolymer is studied using Brownian dynamic simulations. The irreversibly dissipated work is found to be dominated by internal friction effects below the collapse temperature, and the internal viscosity grows exponentially with the effective cohesive strength between monomers. These results explain friction effects of globular DNA and are relevant for dissipation at intermediate stages of protein folding. 2010-02-24T21:17:33Z 2010-02-24T21:17:33Z 2009-07 2007-10 Article http://purl.org/eprint/type/JournalArticle 0031-9007 http://hdl.handle.net/1721.1/51824 Alexander-Katz, Alfredo , Hirofumi Wada, and Roland R. Netz. “Internal Friction and Nonequilibrium Unfolding of Polymeric Globules.” Physical Review Letters 103.2 (2009): 028102. © 2009 The American Physical Society. https://orcid.org/0000-0001-5554-1283 en_US http://dx.doi.org/10.1103/PhysRevLett.103.028102 Physical Review Letters Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf American Physical Society APS |
| spellingShingle | Wada, Hirofumi Netz, Roland R. Alexander-Katz, Alfredo Internal Friction and Nonequilibrium Unfolding of Polymeric Globules |
| title | Internal Friction and Nonequilibrium Unfolding of Polymeric Globules |
| title_full | Internal Friction and Nonequilibrium Unfolding of Polymeric Globules |
| title_fullStr | Internal Friction and Nonequilibrium Unfolding of Polymeric Globules |
| title_full_unstemmed | Internal Friction and Nonequilibrium Unfolding of Polymeric Globules |
| title_short | Internal Friction and Nonequilibrium Unfolding of Polymeric Globules |
| title_sort | internal friction and nonequilibrium unfolding of polymeric globules |
| url | http://hdl.handle.net/1721.1/51824 https://orcid.org/0000-0001-5554-1283 |
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