Diffusion MR tractography of the heart
Histological studies have shown that the myocardium consists of an array of crossing helical fiber tracts. Changes in myocardial fiber architecture occur in ischemic heart disease and heart failure, and can be imaged non-destructively with diffusion-encoded MR. Several diffusion-encoding schemes hav...
| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
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BioMed Central
2010
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| Online Access: | http://hdl.handle.net/1721.1/52532 |
| _version_ | 1826204349123002368 |
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| author | Wedeen, Van J. Sosnovik, David Reese, Timothy G. Dai, Guangping Wang, Ruopeng |
| author2 | Harvard University--MIT Division of Health Sciences and Technology |
| author_facet | Harvard University--MIT Division of Health Sciences and Technology Wedeen, Van J. Sosnovik, David Reese, Timothy G. Dai, Guangping Wang, Ruopeng |
| author_sort | Wedeen, Van J. |
| collection | MIT |
| description | Histological studies have shown that the myocardium consists of an array of crossing helical fiber tracts. Changes in myocardial fiber architecture occur in ischemic heart disease and heart failure, and can be imaged non-destructively with diffusion-encoded MR. Several diffusion-encoding schemes have been developed, ranging from scalar measurements of mean diffusivity to a 6-dimensional imaging technique known as diffusion spectrum imaging or DSI. The properties of DSI make it particularly suited to the generation of 3-dimensional tractograms of myofiber architecture. In this article we review the physical basis of diffusion-tractography in the myocardium and the attributes of the available techniques, placing particular emphasis on DSI. The application of DSI in ischemic heart disease is reviewed, and the requisites for widespread clinical translation of diffusion MR tractography in the heart are discussed. |
| first_indexed | 2024-09-23T12:53:14Z |
| format | Article |
| id | mit-1721.1/52532 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T12:53:14Z |
| publishDate | 2010 |
| publisher | BioMed Central |
| record_format | dspace |
| spelling | mit-1721.1/525322022-10-01T11:43:16Z Diffusion MR tractography of the heart Wedeen, Van J. Sosnovik, David Reese, Timothy G. Dai, Guangping Wang, Ruopeng Harvard University--MIT Division of Health Sciences and Technology Sosnovik, David Wedeen, Van J. Sosnovik, David Histological studies have shown that the myocardium consists of an array of crossing helical fiber tracts. Changes in myocardial fiber architecture occur in ischemic heart disease and heart failure, and can be imaged non-destructively with diffusion-encoded MR. Several diffusion-encoding schemes have been developed, ranging from scalar measurements of mean diffusivity to a 6-dimensional imaging technique known as diffusion spectrum imaging or DSI. The properties of DSI make it particularly suited to the generation of 3-dimensional tractograms of myofiber architecture. In this article we review the physical basis of diffusion-tractography in the myocardium and the attributes of the available techniques, placing particular emphasis on DSI. The application of DSI in ischemic heart disease is reviewed, and the requisites for widespread clinical translation of diffusion MR tractography in the heart are discussed. National Institutes of Health (NCRR P41RR14075) 2010-03-12T15:08:40Z 2010-03-12T15:08:40Z 2009-11 2009-08 Article http://purl.org/eprint/type/JournalArticle 1532-429X http://hdl.handle.net/1721.1/52532 Sosnovik, David et al. “Diffusion MR tractography of the heart.” Journal of Cardiovascular Magnetic Resonance 11.1 (2009): 47. en_US http://dx.doi.org/10.1186/1532-429x-11-47 Journal of Cardiovascular Magnetic Resonance Creative Commons Attribution http://creativecommons.org/licenses/by/2.0/ application/pdf BioMed Central BioMed Central |
| spellingShingle | Wedeen, Van J. Sosnovik, David Reese, Timothy G. Dai, Guangping Wang, Ruopeng Diffusion MR tractography of the heart |
| title | Diffusion MR tractography of the heart |
| title_full | Diffusion MR tractography of the heart |
| title_fullStr | Diffusion MR tractography of the heart |
| title_full_unstemmed | Diffusion MR tractography of the heart |
| title_short | Diffusion MR tractography of the heart |
| title_sort | diffusion mr tractography of the heart |
| url | http://hdl.handle.net/1721.1/52532 |
| work_keys_str_mv | AT wedeenvanj diffusionmrtractographyoftheheart AT sosnovikdavid diffusionmrtractographyoftheheart AT reesetimothyg diffusionmrtractographyoftheheart AT daiguangping diffusionmrtractographyoftheheart AT wangruopeng diffusionmrtractographyoftheheart |