Plk1 Self-Organization and Priming Phosphorylation of HsCYK-4 at the Spindle Midzone Regulate the Onset of Division in Human Cells

Plk1 Self-Organization and Priming Phosphorylation of HsCYK-4 at the Spindle Midzone Regulate the Onset of Division in Human Cells

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Animal cells initiate cytokinesis in parallel with anaphase onset, when an actomyosin ring assembles and constricts through localized activation of the small GTPase RhoA, giving rise to a cleavage furrow. Furrow formation relies on positional cues provided by anaphase spindle microtubules (MTs), but...

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Bibliographic Details
Main Authors: Burkard, Mark E., Maciejowski, John, Rodriguez-Bravo, Veronic, Repka, Michael, Lowery, Drew M., Clauser, Karl R., Shokat, Kevan M., Jallepalli, Prasad V., Zhang, Chao, Ph. D. Massachusetts Institute of Technology, Carr, Steven A, Yaffe, Michael B
Other Authors: Broad Institute of MIT and Harvard
Format: Article
Language:en_US
Published: Public Library of Science 2010
Online Access:http://hdl.handle.net/1721.1/52538
https://orcid.org/0000-0002-7203-4299
https://orcid.org/0000-0002-9547-3251

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