In vivo profiles in malaria are consistent with a novel physiological state
Lemieux et al. (1) describe a reanalysis of our in vivo Plasmodium falciparum patient samples (2), supporting many of our conclusions (exclusive presence of rings, lack of distinct asexual phases in the clusters, a relation between Cluster 1 and gametogenesis). However, Lemieux et al. (1) fit the ob...
| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
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National Academy of Sciences
2010
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| Online Access: | http://hdl.handle.net/1721.1/52563 https://orcid.org/0000-0001-8567-2049 |
| _version_ | 1810998998836707328 |
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| author | Wirth, Dyann Daily, Johanna P. Winzeler, Elizabeth Mesirov, Jill P. Regev, Aviv |
| author2 | Broad Institute of MIT and Harvard |
| author_facet | Broad Institute of MIT and Harvard Wirth, Dyann Daily, Johanna P. Winzeler, Elizabeth Mesirov, Jill P. Regev, Aviv |
| author_sort | Wirth, Dyann |
| collection | MIT |
| description | Lemieux et al. (1) describe a reanalysis of our in vivo Plasmodium falciparum patient samples (2), supporting many of our conclusions (exclusive presence of rings, lack of distinct asexual phases in the clusters, a relation between Cluster 1 and gametogenesis). However, Lemieux et al. (1) fit the observed in vivo profiles as a mixture of gametocyte and asexual form mRNA (Fig. 2E in ref. 1), concluding that the discrete clusters are consistent with varying proportions of sexually committed but phenotypically indistinguishable parasites, reflected by the parameter α. |
| first_indexed | 2024-09-23T14:53:52Z |
| format | Article |
| id | mit-1721.1/52563 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T14:53:52Z |
| publishDate | 2010 |
| publisher | National Academy of Sciences |
| record_format | dspace |
| spelling | mit-1721.1/525632022-10-01T23:14:57Z In vivo profiles in malaria are consistent with a novel physiological state Wirth, Dyann Daily, Johanna P. Winzeler, Elizabeth Mesirov, Jill P. Regev, Aviv Broad Institute of MIT and Harvard Massachusetts Institute of Technology. Department of Biology Koch Institute for Integrative Cancer Research at MIT Regev, Aviv Mesirov, Jill P. Regev, Aviv Lemieux et al. (1) describe a reanalysis of our in vivo Plasmodium falciparum patient samples (2), supporting many of our conclusions (exclusive presence of rings, lack of distinct asexual phases in the clusters, a relation between Cluster 1 and gametogenesis). However, Lemieux et al. (1) fit the observed in vivo profiles as a mixture of gametocyte and asexual form mRNA (Fig. 2E in ref. 1), concluding that the discrete clusters are consistent with varying proportions of sexually committed but phenotypically indistinguishable parasites, reflected by the parameter α. 2010-03-12T21:47:49Z 2010-03-12T21:47:49Z 2009-07 Article http://purl.org/eprint/type/JournalArticle 0027-8424 http://hdl.handle.net/1721.1/52563 Wirth, Dyann et al. “In vivo profiles in malaria are consistent with a novel physiological state.” Proceedings of the National Academy of Sciences 106.27 (2009): E70. ©2009 the National Academy of Sciences 19570993 https://orcid.org/0000-0001-8567-2049 en_US http://dx.doi.org/10.1073/pnas.0904478106 Proceedings of the National Academy of Sciences of the United States of America Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf National Academy of Sciences PNAS |
| spellingShingle | Wirth, Dyann Daily, Johanna P. Winzeler, Elizabeth Mesirov, Jill P. Regev, Aviv In vivo profiles in malaria are consistent with a novel physiological state |
| title | In vivo profiles in malaria are consistent with a novel physiological state |
| title_full | In vivo profiles in malaria are consistent with a novel physiological state |
| title_fullStr | In vivo profiles in malaria are consistent with a novel physiological state |
| title_full_unstemmed | In vivo profiles in malaria are consistent with a novel physiological state |
| title_short | In vivo profiles in malaria are consistent with a novel physiological state |
| title_sort | in vivo profiles in malaria are consistent with a novel physiological state |
| url | http://hdl.handle.net/1721.1/52563 https://orcid.org/0000-0001-8567-2049 |
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