Role of reactive oxygen species in low level light therapy
This review will focus on the role of reactive oxygen species in the cellular and tissue effects of low level light therapy (LLLT). Coincidentally with the increase in electron transport and in ATP, there has also been observed by intracellular fluorescent probes and electron spin resonance an in...
| Main Authors: | , , , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
The International Society for Optical Engineering
2010
|
| Online Access: | http://hdl.handle.net/1721.1/52743 |
| _version_ | 1826190289337843712 |
|---|---|
| author | Hamblin, Michael R. Arany, Praveen R. Huang, Ying-Ying Chen, Aaron Chih-Hao |
| author2 | Harvard University--MIT Division of Health Sciences and Technology |
| author_facet | Harvard University--MIT Division of Health Sciences and Technology Hamblin, Michael R. Arany, Praveen R. Huang, Ying-Ying Chen, Aaron Chih-Hao |
| author_sort | Hamblin, Michael R. |
| collection | MIT |
| description | This review will focus on the role of reactive oxygen species in the cellular and tissue effects of low level light therapy (LLLT). Coincidentally with the increase in electron transport and in ATP, there has also been observed by intracellular fluorescent probes and electron spin resonance an increase in intracellular reactive oxygen species (ROS) such as superoxide, hydrogen peroxide, singlet oxygen and hydroxyl radical. ROS scavengers, antioxidants and ROS quenchers block many LLLT processes. It has been proposed that light between 400-500- nm may produce ROS by a photosensitization process involving flavins, while longer wavelengths may directly produce ROS from the mitochondria. Several redox-sensitive transcription factors are known such as NF-kB and AP1, that are able to initiate transcription of genes involved in protective responses to oxidative stress. It may be the case that LLLT can be pro-oxidant in the short-term, but anti-oxidant in the long-term. |
| first_indexed | 2024-09-23T08:37:38Z |
| format | Article |
| id | mit-1721.1/52743 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T08:37:38Z |
| publishDate | 2010 |
| publisher | The International Society for Optical Engineering |
| record_format | dspace |
| spelling | mit-1721.1/527432022-09-23T13:25:05Z Role of reactive oxygen species in low level light therapy Hamblin, Michael R. Arany, Praveen R. Huang, Ying-Ying Chen, Aaron Chih-Hao Harvard University--MIT Division of Health Sciences and Technology Hamblin, Michael R. Hamblin, Michael R. This review will focus on the role of reactive oxygen species in the cellular and tissue effects of low level light therapy (LLLT). Coincidentally with the increase in electron transport and in ATP, there has also been observed by intracellular fluorescent probes and electron spin resonance an increase in intracellular reactive oxygen species (ROS) such as superoxide, hydrogen peroxide, singlet oxygen and hydroxyl radical. ROS scavengers, antioxidants and ROS quenchers block many LLLT processes. It has been proposed that light between 400-500- nm may produce ROS by a photosensitization process involving flavins, while longer wavelengths may directly produce ROS from the mitochondria. Several redox-sensitive transcription factors are known such as NF-kB and AP1, that are able to initiate transcription of genes involved in protective responses to oxidative stress. It may be the case that LLLT can be pro-oxidant in the short-term, but anti-oxidant in the long-term. United States National Institutes of Health (R01CA/AI838801 and R01 AI050875) 2010-03-19T17:46:21Z 2010-03-19T17:46:21Z 2009-02 Article http://purl.org/eprint/type/JournalArticle 0277-786X http://hdl.handle.net/1721.1/52743 Chen, Aaron Chih-Hao et al. “Role of reactive oxygen species in low level light therapy.” Mechanisms for Low-Light Therapy IV. Ed. Michael R. Hamblin, Ronald W. Waynant, & Juanita Anders. San Jose, CA, USA: SPIE, 2009. 716502-11. © 2009 SPIE--The International Society for Optical Engineering en_US http://dx.doi.org/10.1117/12.814890 Proceedings of SPIE Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf The International Society for Optical Engineering SPIE |
| spellingShingle | Hamblin, Michael R. Arany, Praveen R. Huang, Ying-Ying Chen, Aaron Chih-Hao Role of reactive oxygen species in low level light therapy |
| title | Role of reactive oxygen species in low level light therapy |
| title_full | Role of reactive oxygen species in low level light therapy |
| title_fullStr | Role of reactive oxygen species in low level light therapy |
| title_full_unstemmed | Role of reactive oxygen species in low level light therapy |
| title_short | Role of reactive oxygen species in low level light therapy |
| title_sort | role of reactive oxygen species in low level light therapy |
| url | http://hdl.handle.net/1721.1/52743 |
| work_keys_str_mv | AT hamblinmichaelr roleofreactiveoxygenspeciesinlowlevellighttherapy AT aranypraveenr roleofreactiveoxygenspeciesinlowlevellighttherapy AT huangyingying roleofreactiveoxygenspeciesinlowlevellighttherapy AT chenaaronchihhao roleofreactiveoxygenspeciesinlowlevellighttherapy |