Development and Implantation of a Minimally Invasive Wireless Subretinal Neurostimulator
A wirelessly operated, minimally invasive retinal prosthesis was developed for preclinical chronic implantation studies in Yucatan minipig models. The implant conforms to the outer wall of the eye and drives a microfabricated polyimide stimulating electrode array with sputtered iridium oxide electro...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
Institute of Electrical and Electronics Engineers
2010
|
| Subjects: | |
| Online Access: | http://hdl.handle.net/1721.1/53634 https://orcid.org/0000-0003-0044-4317 |
| _version_ | 1826207896510136320 |
|---|---|
| author | Theogarajan, Luke Wyatt, John L Mendoza, Oscar D. Rizzo, Joseph F. Drohan, William A. Cogan, Stuart F. Gingerich, Marcus D. Doyle, Patrick S. Chen, Jinghua Kelly, Shawn K. Shire, Douglas B. |
| author2 | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science |
| author_facet | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Theogarajan, Luke Wyatt, John L Mendoza, Oscar D. Rizzo, Joseph F. Drohan, William A. Cogan, Stuart F. Gingerich, Marcus D. Doyle, Patrick S. Chen, Jinghua Kelly, Shawn K. Shire, Douglas B. |
| author_sort | Theogarajan, Luke |
| collection | MIT |
| description | A wirelessly operated, minimally invasive retinal prosthesis was developed for preclinical chronic implantation studies in Yucatan minipig models. The implant conforms to the outer wall of the eye and drives a microfabricated polyimide stimulating electrode array with sputtered iridium oxide electrodes. This array is implanted in the subretinal space using a specially designed ab externo surgical technique that fixes the bulk of the prosthesis to the outer surface of the sclera. The implanted device is fabricated on a host polyimide flexible circuit. It consists of a 15-channel stimulator chip, secondary power and data receiving coils, and discrete power supply components. The completed device is encapsulated in poly(dimethylsiloxane) except for the reference/counter electrode and the thin electrode array. In vitro testing was performed to verify the performance of the system in biological saline using a custom RF transmitter circuit and primary coils. Stimulation patterns as well as pulse strength, duration, and frequency were programmed wirelessly using custom software and a graphical user interface. Wireless operation of the retinal implant has been verified both in vitro and in vivo in three pigs for more than seven months, the latter by measuring stimulus artifacts on the eye surface using contact lens electrodes. |
| first_indexed | 2024-09-23T13:56:40Z |
| format | Article |
| id | mit-1721.1/53634 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T13:56:40Z |
| publishDate | 2010 |
| publisher | Institute of Electrical and Electronics Engineers |
| record_format | dspace |
| spelling | mit-1721.1/536342022-09-28T17:15:45Z Development and Implantation of a Minimally Invasive Wireless Subretinal Neurostimulator Theogarajan, Luke Wyatt, John L Mendoza, Oscar D. Rizzo, Joseph F. Drohan, William A. Cogan, Stuart F. Gingerich, Marcus D. Doyle, Patrick S. Chen, Jinghua Kelly, Shawn K. Shire, Douglas B. Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology. Research Laboratory of Electronics Wyatt, John L Theogarajan, Luke Wyatt, John L Mendoza, Oscar D. subretinal stimulation retinal prosthesis retinal implant neural prosthesis Electrode array A wirelessly operated, minimally invasive retinal prosthesis was developed for preclinical chronic implantation studies in Yucatan minipig models. The implant conforms to the outer wall of the eye and drives a microfabricated polyimide stimulating electrode array with sputtered iridium oxide electrodes. This array is implanted in the subretinal space using a specially designed ab externo surgical technique that fixes the bulk of the prosthesis to the outer surface of the sclera. The implanted device is fabricated on a host polyimide flexible circuit. It consists of a 15-channel stimulator chip, secondary power and data receiving coils, and discrete power supply components. The completed device is encapsulated in poly(dimethylsiloxane) except for the reference/counter electrode and the thin electrode array. In vitro testing was performed to verify the performance of the system in biological saline using a custom RF transmitter circuit and primary coils. Stimulation patterns as well as pulse strength, duration, and frequency were programmed wirelessly using custom software and a graphical user interface. Wireless operation of the retinal implant has been verified both in vitro and in vivo in three pigs for more than seven months, the latter by measuring stimulus artifacts on the eye surface using contact lens electrodes. National Institutes of Health (EY016674-01) National Science Foundation (IIS-0515134) Veterans Affairs Center for Innovative Visual Rehabilitation 2010-04-08T19:55:50Z 2010-04-08T19:55:50Z 2009-09 2009-02 Article http://purl.org/eprint/type/JournalArticle 0018-9294 http://hdl.handle.net/1721.1/53634 Shire, D.B. et al. “Development and Implantation of a Minimally Invasive Wireless Subretinal Neurostimulator.” Biomedical Engineering, IEEE Transactions on 56.10 (2009): 2502-2511. © 2009 IEEE https://orcid.org/0000-0003-0044-4317 en_US http://dx.doi.org/10.1109/tbme.2009.2021401 IEEE Transactions on Biomedical Engineering Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf Institute of Electrical and Electronics Engineers IEEE |
| spellingShingle | subretinal stimulation retinal prosthesis retinal implant neural prosthesis Electrode array Theogarajan, Luke Wyatt, John L Mendoza, Oscar D. Rizzo, Joseph F. Drohan, William A. Cogan, Stuart F. Gingerich, Marcus D. Doyle, Patrick S. Chen, Jinghua Kelly, Shawn K. Shire, Douglas B. Development and Implantation of a Minimally Invasive Wireless Subretinal Neurostimulator |
| title | Development and Implantation of a Minimally Invasive Wireless Subretinal Neurostimulator |
| title_full | Development and Implantation of a Minimally Invasive Wireless Subretinal Neurostimulator |
| title_fullStr | Development and Implantation of a Minimally Invasive Wireless Subretinal Neurostimulator |
| title_full_unstemmed | Development and Implantation of a Minimally Invasive Wireless Subretinal Neurostimulator |
| title_short | Development and Implantation of a Minimally Invasive Wireless Subretinal Neurostimulator |
| title_sort | development and implantation of a minimally invasive wireless subretinal neurostimulator |
| topic | subretinal stimulation retinal prosthesis retinal implant neural prosthesis Electrode array |
| url | http://hdl.handle.net/1721.1/53634 https://orcid.org/0000-0003-0044-4317 |
| work_keys_str_mv | AT theogarajanluke developmentandimplantationofaminimallyinvasivewirelesssubretinalneurostimulator AT wyattjohnl developmentandimplantationofaminimallyinvasivewirelesssubretinalneurostimulator AT mendozaoscard developmentandimplantationofaminimallyinvasivewirelesssubretinalneurostimulator AT rizzojosephf developmentandimplantationofaminimallyinvasivewirelesssubretinalneurostimulator AT drohanwilliama developmentandimplantationofaminimallyinvasivewirelesssubretinalneurostimulator AT coganstuartf developmentandimplantationofaminimallyinvasivewirelesssubretinalneurostimulator AT gingerichmarcusd developmentandimplantationofaminimallyinvasivewirelesssubretinalneurostimulator AT doylepatricks developmentandimplantationofaminimallyinvasivewirelesssubretinalneurostimulator AT chenjinghua developmentandimplantationofaminimallyinvasivewirelesssubretinalneurostimulator AT kellyshawnk developmentandimplantationofaminimallyinvasivewirelesssubretinalneurostimulator AT shiredouglasb developmentandimplantationofaminimallyinvasivewirelesssubretinalneurostimulator |