Ultrahigh speed spectral / Fourier domain ophthalmic OCT imaging
Ultrahigh speed spectral / Fourier domain optical coherence tomography (OCT) imaging using a CMOS line scan camera with acquisition rates of 70,000 - 312,500 axial scans per second is investigated. Several design configurations are presented to illustrate trade-offs between acquisition speed, sensit...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | en_US |
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Society of Photo-optical Instrumentation Engineers
2010
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| Online Access: | http://hdl.handle.net/1721.1/54764 https://orcid.org/0000-0002-0828-4357 |
| _version_ | 1826200361718775808 |
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| author | Chen, Yueli Srinivasan, Vivek J. Gorczynska, Iwona Liu, Jonathan Jaoshin Fujimoto, James G. Potsaid, Benjamin M. Duker, Jay S. Cable, Alex E. Jiang, James |
| author2 | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science |
| author_facet | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Chen, Yueli Srinivasan, Vivek J. Gorczynska, Iwona Liu, Jonathan Jaoshin Fujimoto, James G. Potsaid, Benjamin M. Duker, Jay S. Cable, Alex E. Jiang, James |
| author_sort | Chen, Yueli |
| collection | MIT |
| description | Ultrahigh speed spectral / Fourier domain optical coherence tomography (OCT) imaging using a CMOS line scan camera with acquisition rates of 70,000 - 312,500 axial scans per second is investigated. Several design configurations are presented to illustrate trade-offs between acquisition speed, sensitivity, resolution and sensitivity roll-off performance. We demonstrate: extended imaging range and improved sensitivity roll-off at 70,000 axial scans per second , high speed and ultrahigh resolution imaging at 106,382 axial scans per second, and ultrahigh speed imaging at 250,000-312,500 axial scans per second. Each configuration is characterized through optical testing and the trade-offs demonstrated with in vivo imaging of the fovea and optic disk in the human retina. OCT fundus images constructed from 3D-OCT data acquired at 250,000 axial scans per second have no noticeable discontinuity of retinal features and show that there are minimal motion artifacts. The fine structures of the lamina cribrosa can be seen. Long cross sectional scans are acquired at 70,000 axial scans per second for imaging large areas of the retina, including the fovea and optic disk. Rapid repeated imaging of a small volume (4D-OCT) enables time resolved visualization of the capillary network surrounding the INL and may show individual red blood cells. The results of this study suggest that high speed CMOS cameras can achieve a significant improvement in performance for ophthalmic imaging. This promises to have a powerful impact in clinical applications by improving early diagnosis, reproducibility of measurements and enabling more sensitive assessment of disease progression or response to therapy. |
| first_indexed | 2024-09-23T11:35:13Z |
| format | Article |
| id | mit-1721.1/54764 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T11:35:13Z |
| publishDate | 2010 |
| publisher | Society of Photo-optical Instrumentation Engineers |
| record_format | dspace |
| spelling | mit-1721.1/547642022-09-27T20:30:40Z Ultrahigh speed spectral / Fourier domain ophthalmic OCT imaging Ultrahigh Speed Spectral / Fourier Domain Ophthalmic OCT Imaging Chen, Yueli Srinivasan, Vivek J. Gorczynska, Iwona Liu, Jonathan Jaoshin Fujimoto, James G. Potsaid, Benjamin M. Duker, Jay S. Cable, Alex E. Jiang, James Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology. Research Laboratory of Electronics Fujimoto, James G. Chen, Yueli Srinivasan, Vivek J. Gorczynska, Iwona Liu, Jonathan Jaoshin Fujimoto, James G. Potsaid, Benjamin M. Ultrahigh speed spectral / Fourier domain optical coherence tomography (OCT) imaging using a CMOS line scan camera with acquisition rates of 70,000 - 312,500 axial scans per second is investigated. Several design configurations are presented to illustrate trade-offs between acquisition speed, sensitivity, resolution and sensitivity roll-off performance. We demonstrate: extended imaging range and improved sensitivity roll-off at 70,000 axial scans per second , high speed and ultrahigh resolution imaging at 106,382 axial scans per second, and ultrahigh speed imaging at 250,000-312,500 axial scans per second. Each configuration is characterized through optical testing and the trade-offs demonstrated with in vivo imaging of the fovea and optic disk in the human retina. OCT fundus images constructed from 3D-OCT data acquired at 250,000 axial scans per second have no noticeable discontinuity of retinal features and show that there are minimal motion artifacts. The fine structures of the lamina cribrosa can be seen. Long cross sectional scans are acquired at 70,000 axial scans per second for imaging large areas of the retina, including the fovea and optic disk. Rapid repeated imaging of a small volume (4D-OCT) enables time resolved visualization of the capillary network surrounding the INL and may show individual red blood cells. The results of this study suggest that high speed CMOS cameras can achieve a significant improvement in performance for ophthalmic imaging. This promises to have a powerful impact in clinical applications by improving early diagnosis, reproducibility of measurements and enabling more sensitive assessment of disease progression or response to therapy. Medical Free Electron Laser Program (contract FA9550-07-1-0101) United States. Air Force Office of Scientific Research (contract FA9550-07-1-0014) National Science Foundation (BES-0522845) United States. National Institutes of Health (R01-EY11289-21, R01-EY13178-07, R01-CA75289-11) 2010-05-12T15:24:39Z 2010-05-12T15:24:39Z 2009-02 Article http://purl.org/eprint/type/JournalArticle 0277-786X http://hdl.handle.net/1721.1/54764 Potsaid, Benjamin et al. “Ultrahigh speed spectral/Fourier domain ophthalmic OCT imaging.” Ophthalmic Technologies XIX. Ed. Fabrice Manns, Per G. Soderberg, & Arthur Ho. San Jose, CA, USA: SPIE, 2009. 716307-12. © 2009 SPIE https://orcid.org/0000-0002-0828-4357 en_US http://dx.doi.org/10.1117/12.809058 Proceedings of SPIE--the International Society for Optical Engineering Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf Society of Photo-optical Instrumentation Engineers SPIE |
| spellingShingle | Chen, Yueli Srinivasan, Vivek J. Gorczynska, Iwona Liu, Jonathan Jaoshin Fujimoto, James G. Potsaid, Benjamin M. Duker, Jay S. Cable, Alex E. Jiang, James Ultrahigh speed spectral / Fourier domain ophthalmic OCT imaging |
| title | Ultrahigh speed spectral / Fourier domain ophthalmic OCT imaging |
| title_full | Ultrahigh speed spectral / Fourier domain ophthalmic OCT imaging |
| title_fullStr | Ultrahigh speed spectral / Fourier domain ophthalmic OCT imaging |
| title_full_unstemmed | Ultrahigh speed spectral / Fourier domain ophthalmic OCT imaging |
| title_short | Ultrahigh speed spectral / Fourier domain ophthalmic OCT imaging |
| title_sort | ultrahigh speed spectral fourier domain ophthalmic oct imaging |
| url | http://hdl.handle.net/1721.1/54764 https://orcid.org/0000-0002-0828-4357 |
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