Unraveling Infectious Structures, Strain Variants and Species Barriers for the Yeast Prion [PSI+]
Prions are proteins that can access multiple conformations, at least one of which is beta-sheet rich, infectious and self-perpetuating in nature. These infectious proteins show several remarkable biological activities, including the ability to form multiple infectious prion conformations, also known...
| Main Authors: | , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
Nature Publishing Group
2010
|
| Online Access: | http://hdl.handle.net/1721.1/54769 https://orcid.org/0000-0003-1307-882X |
| _version_ | 1826217925612142592 |
|---|---|
| author | Lindquist, Susan Tessier, Peter M. |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Lindquist, Susan Tessier, Peter M. |
| author_sort | Lindquist, Susan |
| collection | MIT |
| description | Prions are proteins that can access multiple conformations, at least one of which is beta-sheet rich, infectious and self-perpetuating in nature. These infectious proteins show several remarkable biological activities, including the ability to form multiple infectious prion conformations, also known as strains or variants, encoding unique biological phenotypes, and to establish and overcome prion species (transmission) barriers. In this Perspective, we highlight recent studies of the yeast prion [PSI+], using various biochemical and structural methods, that have begun to illuminate the molecular mechanisms by which self-perpetuating prions encipher such biological activities. We also discuss several aspects of prion conformational change and structure that remain either unknown or controversial, and we propose approaches to accelerate the understanding of these enigmatic, infectious conformers. |
| first_indexed | 2024-09-23T17:11:14Z |
| format | Article |
| id | mit-1721.1/54769 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T17:11:14Z |
| publishDate | 2010 |
| publisher | Nature Publishing Group |
| record_format | dspace |
| spelling | mit-1721.1/547692022-10-03T11:00:04Z Unraveling Infectious Structures, Strain Variants and Species Barriers for the Yeast Prion [PSI+] Unraveling infectious structures, strain variants and species barriers for the yeast prion [PSI+] Lindquist, Susan Tessier, Peter M. Massachusetts Institute of Technology. Department of Biology Lindquist, Susan Lindquist, Susan Prions are proteins that can access multiple conformations, at least one of which is beta-sheet rich, infectious and self-perpetuating in nature. These infectious proteins show several remarkable biological activities, including the ability to form multiple infectious prion conformations, also known as strains or variants, encoding unique biological phenotypes, and to establish and overcome prion species (transmission) barriers. In this Perspective, we highlight recent studies of the yeast prion [PSI+], using various biochemical and structural methods, that have begun to illuminate the molecular mechanisms by which self-perpetuating prions encipher such biological activities. We also discuss several aspects of prion conformational change and structure that remain either unknown or controversial, and we propose approaches to accelerate the understanding of these enigmatic, infectious conformers. 2010-05-12T17:45:08Z 2010-05-12T17:45:08Z 2009-06 Article http://purl.org/eprint/type/SubmittedJournalArticle 1545-9985 1545-9993 http://hdl.handle.net/1721.1/54769 Tessier, Peter M, and Susan Lindquist. “Unraveling infectious structures, strain variants and species barriers for the yeast prion [PSI+].” Nat Struct Mol Biol 16.6 (2009): 598-605. https://orcid.org/0000-0003-1307-882X en_US http://dx.doi.org/10.1038/nsmb.1617 Nature Structural & Molecular Biology Attribution-Noncommercial-Share Alike 3.0 Unported http://creativecommons.org/licenses/by-nc-sa/3.0/ application/pdf Nature Publishing Group S. Lindquist |
| spellingShingle | Lindquist, Susan Tessier, Peter M. Unraveling Infectious Structures, Strain Variants and Species Barriers for the Yeast Prion [PSI+] |
| title | Unraveling Infectious Structures, Strain Variants and Species Barriers for the Yeast Prion [PSI+] |
| title_full | Unraveling Infectious Structures, Strain Variants and Species Barriers for the Yeast Prion [PSI+] |
| title_fullStr | Unraveling Infectious Structures, Strain Variants and Species Barriers for the Yeast Prion [PSI+] |
| title_full_unstemmed | Unraveling Infectious Structures, Strain Variants and Species Barriers for the Yeast Prion [PSI+] |
| title_short | Unraveling Infectious Structures, Strain Variants and Species Barriers for the Yeast Prion [PSI+] |
| title_sort | unraveling infectious structures strain variants and species barriers for the yeast prion psi |
| url | http://hdl.handle.net/1721.1/54769 https://orcid.org/0000-0003-1307-882X |
| work_keys_str_mv | AT lindquistsusan unravelinginfectiousstructuresstrainvariantsandspeciesbarriersfortheyeastprionpsi AT tessierpeterm unravelinginfectiousstructuresstrainvariantsandspeciesbarriersfortheyeastprionpsi |