Rapid Selection of Cyclic Peptides that Reduce Alpha-Synuclein Toxicity in Yeast and Animal Models

Rapid Selection of Cyclic Peptides that Reduce Alpha-Synuclein Toxicity in Yeast and Animal Models

Phage display has demonstrated the utility of cyclic peptides as general protein ligands but cannot access proteins inside eukaryotic cells. Expanding a new chemical genetics tool, we describe the first expressed library of head-to-tail cyclic peptides in yeast (Saccharomyces cerevisiae). We applied...

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Bibliographic Details
Main Authors: Lindquist, Susan, Caldwell, Guy A., Caldwell, Kim A., Naumann, Todd A., Santagata, Sandro, McCaffery, J. Michael, Hamamichi, Shusei, Kritzer, Joshua A.
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Nature Publishing Group 2010
Online Access:http://hdl.handle.net/1721.1/54774
https://orcid.org/0000-0003-1307-882X

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http://hdl.handle.net/1721.1/54774
https://orcid.org/0000-0003-1307-882X

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