Ex vivo Imaging of Human Pathologies with Integrated Optical Coherence Tomography (OCT) and Optical Coherence Microscopy (OCM)
We report an imaging study using integrated 3D-OCT and OCM for the assessment of various human thyroid and breast pathologies. The 3D-OCT data sets enable en face projection imaging, which provides large field of view with uniform focus and signal level, while OCM provides high magnification that en...
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| Format: | Article |
| Language: | en_US |
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Society of Photo-optical Instrumentation Engineers
2010
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| Online Access: | http://hdl.handle.net/1721.1/54788 https://orcid.org/0000-0002-0828-4357 |
| _version_ | 1811076596674592768 |
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| author | Bryan, Bradley Wang, Yihong Connolly, James L. Zhou, Chao Aguirre, Aaron Dominic Tsai, Tsung-Han Fujimoto, James G. |
| author2 | Harvard University--MIT Division of Health Sciences and Technology |
| author_facet | Harvard University--MIT Division of Health Sciences and Technology Bryan, Bradley Wang, Yihong Connolly, James L. Zhou, Chao Aguirre, Aaron Dominic Tsai, Tsung-Han Fujimoto, James G. |
| author_sort | Bryan, Bradley |
| collection | MIT |
| description | We report an imaging study using integrated 3D-OCT and OCM for the assessment of various human thyroid and breast pathologies. The 3D-OCT data sets enable en face projection imaging, which provides large field of view with uniform focus and signal level, while OCM provides high magnification that enables cellular resolution imaging. We have demonstrated that the integrated 3D-OCT and OCM technology provide a substantial improvement over standard OCT for the visualization of tissue pathology and can serve as a useful imaging tool in the clinical settings. |
| first_indexed | 2024-09-23T10:24:39Z |
| format | Article |
| id | mit-1721.1/54788 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T10:24:39Z |
| publishDate | 2010 |
| publisher | Society of Photo-optical Instrumentation Engineers |
| record_format | dspace |
| spelling | mit-1721.1/547882022-09-26T17:40:49Z Ex vivo Imaging of Human Pathologies with Integrated Optical Coherence Tomography (OCT) and Optical Coherence Microscopy (OCM) Bryan, Bradley Wang, Yihong Connolly, James L. Zhou, Chao Aguirre, Aaron Dominic Tsai, Tsung-Han Fujimoto, James G. Harvard University--MIT Division of Health Sciences and Technology Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology. Research Laboratory of Electronics Fujimoto, James G. Zhou, Chao Aguirre, Aaron Dominic Tsai, Tsung-Han Fujimoto, James G. We report an imaging study using integrated 3D-OCT and OCM for the assessment of various human thyroid and breast pathologies. The 3D-OCT data sets enable en face projection imaging, which provides large field of view with uniform focus and signal level, while OCM provides high magnification that enables cellular resolution imaging. We have demonstrated that the integrated 3D-OCT and OCM technology provide a substantial improvement over standard OCT for the visualization of tissue pathology and can serve as a useful imaging tool in the clinical settings. Medical Free Electron Laser Program (contract FA9550-07- 1-0101 (JGF)) United States. Air Force Office of Scientific Research (contract FA9550-07-1-0014 (JGF)) United States. National Institutes of Health (grants R01-CA75289-12 (JGF and JLC)) 2010-05-13T19:52:04Z 2010-05-13T19:52:04Z 2009-02 2009-01 Article http://purl.org/eprint/type/JournalArticle 9780819474148 0819474142 0361-0748 http://hdl.handle.net/1721.1/54788 Zhou, Chao et al. “Ex vivo imaging of human pathologies with integrated optical coherence tomography (OCT) and optical coherence microscopy (OCM).” Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIII. Ed. James G. Fujimoto, Joseph A. Izatt, & Valery V. Tuchin. San Jose, CA, USA: SPIE, 2009. 71680N-8. © 2009 Society of Photo-optical Instrumentation Engineers. https://orcid.org/0000-0002-0828-4357 en_US http://dx.doi.org/10.1117/12.809064 Proceedings of the Society of Photo-optical Instrumentation Engineers Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf Society of Photo-optical Instrumentation Engineers SPIE |
| spellingShingle | Bryan, Bradley Wang, Yihong Connolly, James L. Zhou, Chao Aguirre, Aaron Dominic Tsai, Tsung-Han Fujimoto, James G. Ex vivo Imaging of Human Pathologies with Integrated Optical Coherence Tomography (OCT) and Optical Coherence Microscopy (OCM) |
| title | Ex vivo Imaging of Human Pathologies with Integrated Optical Coherence Tomography (OCT) and Optical Coherence Microscopy (OCM) |
| title_full | Ex vivo Imaging of Human Pathologies with Integrated Optical Coherence Tomography (OCT) and Optical Coherence Microscopy (OCM) |
| title_fullStr | Ex vivo Imaging of Human Pathologies with Integrated Optical Coherence Tomography (OCT) and Optical Coherence Microscopy (OCM) |
| title_full_unstemmed | Ex vivo Imaging of Human Pathologies with Integrated Optical Coherence Tomography (OCT) and Optical Coherence Microscopy (OCM) |
| title_short | Ex vivo Imaging of Human Pathologies with Integrated Optical Coherence Tomography (OCT) and Optical Coherence Microscopy (OCM) |
| title_sort | ex vivo imaging of human pathologies with integrated optical coherence tomography oct and optical coherence microscopy ocm |
| url | http://hdl.handle.net/1721.1/54788 https://orcid.org/0000-0002-0828-4357 |
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