A Mitotic Phosphorylation Feedback Network Connects Cdk1, Plk1, 53BP1, and Chk2 to Inactivate the G2/M DNA Damage Checkpoint

A Mitotic Phosphorylation Feedback Network Connects Cdk1, Plk1, 53BP1, and Chk2 to Inactivate the G2/M DNA Damage Checkpoint

DNA damage checkpoints arrest cell cycle progression to facilitate DNA repair. The ability to survive genotoxic insults depends not only on the initiation of cell cycle checkpoints but also on checkpoint maintenance. While activation of DNA damage checkpoints has been studied extensively, molecular...

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Bibliographic Details
Main Authors: Yaffe, Michael B., Brummelkamp, Thijn R., Reinhardt, Hans, Ostheimer, Gerard, Gardino, Alexandra Kate, van Vugt, Marcel A. T. M., Smerdon, Stephen J., Carr, Steven A., Lewis, Timothy A., Pawson, Tony, Li, Jeijin, Keezer, Susan M., Miao, Hua, Tan, Chris S., Ong, Shao-En, Linding, Rune
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: Public Library of Science 2010
Online Access:http://hdl.handle.net/1721.1/55355
https://orcid.org/0000-0002-3202-4678
https://orcid.org/0000-0002-9547-3251

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