Toward Imaging Biomarkers for Glycosaminoglycans
Advances in the diagnosis and treatment of cartilage degeneration will be accelerated with the availability of validated biomarkers that reveal the features relevant to the health of cartilage. Using the delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) technique for eval...
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
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Journal of Bone and Joint Surgery, Inc.
2010
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| Online Access: | http://hdl.handle.net/1721.1/55392 https://orcid.org/0000-0003-2951-6943 |
| _version_ | 1826198841484902400 |
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| author | Gray, Martha L. |
| author2 | Harvard University--MIT Division of Health Sciences and Technology |
| author_facet | Harvard University--MIT Division of Health Sciences and Technology Gray, Martha L. |
| author_sort | Gray, Martha L. |
| collection | MIT |
| description | Advances in the diagnosis and treatment of cartilage degeneration will be accelerated with the availability of validated biomarkers that reveal the features relevant to the health of cartilage. Using the delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) technique for evaluating tissue glycosaminoglycan as a case study, I review the types of evidence needed to validate imaging (or other) biomarkers. In addition, I present discussions about face validity and technical validity and offer a review of emerging data that provide pathophysiologic validity. Examples of such data include evidence that glycosaminoglycan content is restored after an injury-induced loss and evidence suggesting that dGEMRIC can indicate when it is too late for protective (load-modifying) surgery. These and other data suggest that new imaging biomarkers may indeed be able to provide a state-of-cartilage proxy that can be of use in the diagnosis and staging of disease. |
| first_indexed | 2024-09-23T11:10:49Z |
| format | Article |
| id | mit-1721.1/55392 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T11:10:49Z |
| publishDate | 2010 |
| publisher | Journal of Bone and Joint Surgery, Inc. |
| record_format | dspace |
| spelling | mit-1721.1/553922022-10-01T01:51:53Z Toward Imaging Biomarkers for Glycosaminoglycans Gray, Martha L. Harvard University--MIT Division of Health Sciences and Technology Gray, Martha L. Gray, Martha L. Advances in the diagnosis and treatment of cartilage degeneration will be accelerated with the availability of validated biomarkers that reveal the features relevant to the health of cartilage. Using the delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) technique for evaluating tissue glycosaminoglycan as a case study, I review the types of evidence needed to validate imaging (or other) biomarkers. In addition, I present discussions about face validity and technical validity and offer a review of emerging data that provide pathophysiologic validity. Examples of such data include evidence that glycosaminoglycan content is restored after an injury-induced loss and evidence suggesting that dGEMRIC can indicate when it is too late for protective (load-modifying) surgery. These and other data suggest that new imaging biomarkers may indeed be able to provide a state-of-cartilage proxy that can be of use in the diagnosis and staging of disease. Pfizer Proctor and Gamble National Science Foundation National Institutes of Health (U.S.) 2010-06-03T20:38:12Z 2010-06-03T20:38:12Z 2009 Article http://purl.org/eprint/type/JournalArticle 0021-9355 http://hdl.handle.net/1721.1/55392 Gray, Martha L. “Toward Imaging Biomarkers for Glycosaminoglycans.” J Bone Joint Surg Am 91.Supplement_1 (2009): 44-49. © 2009 Journal of Bone and Joint Surgery, Inc. https://orcid.org/0000-0003-2951-6943 en_US http://dx.doi.org/10.2106/jbjs.h.01498 Journal of Bone and Joint Surgery, American Volume Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf Journal of Bone and Joint Surgery, Inc. JBJS |
| spellingShingle | Gray, Martha L. Toward Imaging Biomarkers for Glycosaminoglycans |
| title | Toward Imaging Biomarkers for Glycosaminoglycans |
| title_full | Toward Imaging Biomarkers for Glycosaminoglycans |
| title_fullStr | Toward Imaging Biomarkers for Glycosaminoglycans |
| title_full_unstemmed | Toward Imaging Biomarkers for Glycosaminoglycans |
| title_short | Toward Imaging Biomarkers for Glycosaminoglycans |
| title_sort | toward imaging biomarkers for glycosaminoglycans |
| url | http://hdl.handle.net/1721.1/55392 https://orcid.org/0000-0003-2951-6943 |
| work_keys_str_mv | AT graymarthal towardimagingbiomarkersforglycosaminoglycans |