Performance-Related Sustained and Anticipatory Activity in Human Medial Temporal Lobe during Delayed Match-to-Sample
The medial temporal lobe (MTL)—hippocampus and surrounding perirhinal, parahippocampal, and entorhinal cortical areas—has long been known to be critical for long-term memory for events. Recent functional neuroimaging and neuropsychological data in humans performing short-delay tasks suggest that the...
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| Format: | Article |
| Language: | en_US |
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Society for Neuroscience
2010
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| Online Access: | http://hdl.handle.net/1721.1/55964 https://orcid.org/0000-0003-1158-5692 |
| _version_ | 1826204450385035264 |
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| author | Olsen, Rosanna K. Nichols, Elizabeth A. Chen, Janice Hunt, Jack F. Glover, Gary H. Wagner, Anthony D. Gabrieli, John D. E. |
| author2 | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
| author_facet | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Olsen, Rosanna K. Nichols, Elizabeth A. Chen, Janice Hunt, Jack F. Glover, Gary H. Wagner, Anthony D. Gabrieli, John D. E. |
| author_sort | Olsen, Rosanna K. |
| collection | MIT |
| description | The medial temporal lobe (MTL)—hippocampus and surrounding perirhinal, parahippocampal, and entorhinal cortical areas—has long been known to be critical for long-term memory for events. Recent functional neuroimaging and neuropsychological data in humans performing short-delay tasks suggest that the MTL also contributes to performance even when retention intervals are brief, and single-unit data in rodents reveal sustained, performance-related delay activity in the MTL during delayed-non-match-to-sample tasks. The current study used functional magnetic resonance imaging to examine the relationship between activation in human MTL subregions and performance during a delayed-match-to-sample task with repeated (non-trial-unique) stimuli. On critical trials, the presentation of two faces was followed by a 30 s delay period, after which participants performed two-alternative forced-choice recognition. Functional magnetic resonance imaging revealed significant delay period activity in anterior hippocampus, entorhinal cortex, and perirhinal cortex over the 30 s retention interval, with the magnitude of activity being significantly higher on subsequently correct compared with subsequently incorrect trials. In contrast, posterior hippocampus, parahippocampal cortex, and fusiform gyrus activity linearly increased across the 30 s delay, suggesting an anticipatory response, and activity in parahippocampal cortex and hippocampus was greater during the probe period on correct compared with incorrect trials. These results indicate that at least two patterns of MTL delay period activation—sustained and anticipatory—are present during performance of short-delay recognition memory tasks, providing novel evidence that multiple processes govern task performance. Implications for understanding the role of the hippocampus and surrounding MTL cortical areas in recognition memory after short delays are discussed. |
| first_indexed | 2024-09-23T12:55:15Z |
| format | Article |
| id | mit-1721.1/55964 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T12:55:15Z |
| publishDate | 2010 |
| publisher | Society for Neuroscience |
| record_format | dspace |
| spelling | mit-1721.1/559642022-09-28T10:55:10Z Performance-Related Sustained and Anticipatory Activity in Human Medial Temporal Lobe during Delayed Match-to-Sample Olsen, Rosanna K. Nichols, Elizabeth A. Chen, Janice Hunt, Jack F. Glover, Gary H. Wagner, Anthony D. Gabrieli, John D. E. Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Gabrieli, John D. E. Gabrieli, John D. E. The medial temporal lobe (MTL)—hippocampus and surrounding perirhinal, parahippocampal, and entorhinal cortical areas—has long been known to be critical for long-term memory for events. Recent functional neuroimaging and neuropsychological data in humans performing short-delay tasks suggest that the MTL also contributes to performance even when retention intervals are brief, and single-unit data in rodents reveal sustained, performance-related delay activity in the MTL during delayed-non-match-to-sample tasks. The current study used functional magnetic resonance imaging to examine the relationship between activation in human MTL subregions and performance during a delayed-match-to-sample task with repeated (non-trial-unique) stimuli. On critical trials, the presentation of two faces was followed by a 30 s delay period, after which participants performed two-alternative forced-choice recognition. Functional magnetic resonance imaging revealed significant delay period activity in anterior hippocampus, entorhinal cortex, and perirhinal cortex over the 30 s retention interval, with the magnitude of activity being significantly higher on subsequently correct compared with subsequently incorrect trials. In contrast, posterior hippocampus, parahippocampal cortex, and fusiform gyrus activity linearly increased across the 30 s delay, suggesting an anticipatory response, and activity in parahippocampal cortex and hippocampus was greater during the probe period on correct compared with incorrect trials. These results indicate that at least two patterns of MTL delay period activation—sustained and anticipatory—are present during performance of short-delay recognition memory tasks, providing novel evidence that multiple processes govern task performance. Implications for understanding the role of the hippocampus and surrounding MTL cortical areas in recognition memory after short delays are discussed. National Institute of Mental Health (Grant 5R01-MH076932) National Science Foundation National Alliance for Research on Schizophrenia and Depression Alfred P. Sloan Foundation 2010-06-25T15:13:59Z 2010-06-25T15:13:59Z 2009-09 2009-08 Article http://purl.org/eprint/type/JournalArticle 1529-2401 http://hdl.handle.net/1721.1/55964 Olsen, Rosanna K et al. “Performance-Related Sustained and Anticipatory Activity in Human Medial Temporal Lobe during Delayed Match-to-Sample.” J. Neurosci. 29.38 (2009): 11880-11890. © 2009 The Society for Neuroscience https://orcid.org/0000-0003-1158-5692 en_US http://dx.doi.org/10.1523/jneurosci.2245-09.2009 Journal of Neuroscience Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf Society for Neuroscience Society for Neuroscience |
| spellingShingle | Olsen, Rosanna K. Nichols, Elizabeth A. Chen, Janice Hunt, Jack F. Glover, Gary H. Wagner, Anthony D. Gabrieli, John D. E. Performance-Related Sustained and Anticipatory Activity in Human Medial Temporal Lobe during Delayed Match-to-Sample |
| title | Performance-Related Sustained and Anticipatory Activity in Human Medial Temporal Lobe during Delayed Match-to-Sample |
| title_full | Performance-Related Sustained and Anticipatory Activity in Human Medial Temporal Lobe during Delayed Match-to-Sample |
| title_fullStr | Performance-Related Sustained and Anticipatory Activity in Human Medial Temporal Lobe during Delayed Match-to-Sample |
| title_full_unstemmed | Performance-Related Sustained and Anticipatory Activity in Human Medial Temporal Lobe during Delayed Match-to-Sample |
| title_short | Performance-Related Sustained and Anticipatory Activity in Human Medial Temporal Lobe during Delayed Match-to-Sample |
| title_sort | performance related sustained and anticipatory activity in human medial temporal lobe during delayed match to sample |
| url | http://hdl.handle.net/1721.1/55964 https://orcid.org/0000-0003-1158-5692 |
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