A critical period for activity-dependent synaptic development during olfactory bulb adult neurogenesis
New neurons integrate in large numbers into the mature olfactory bulb circuit throughout life. The factors controlling the synaptic development of adult-born neurons and their connectivity remain essentially unknown. We examined the role of activity-dependent mechanisms in the synaptic development o...
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| Aineistotyyppi: | Artikkeli |
| Kieli: | en_US |
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Society for Neuroscience
2010
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| Linkit: | http://hdl.handle.net/1721.1/55968 https://orcid.org/0000-0002-3470-8125 |
| _version_ | 1826215590012911616 |
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| author | Kelsch, Wolfgang Lin, Chia-Wei Mosley, Colleen P. Lois, Carlos |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Kelsch, Wolfgang Lin, Chia-Wei Mosley, Colleen P. Lois, Carlos |
| author_sort | Kelsch, Wolfgang |
| collection | MIT |
| description | New neurons integrate in large numbers into the mature olfactory bulb circuit throughout life. The factors controlling the synaptic development of adult-born neurons and their connectivity remain essentially unknown. We examined the role of activity-dependent mechanisms in the synaptic development of adult-born neurons by genetic labeling of synapses while manipulating sensory input or cell-intrinsic excitability. Sensory deprivation induced marked changes in the density of input and output synapses during the period when new neurons develop most of their synapses. In contrast, when sensory deprivation started after synaptic formation was complete, input synapses increased in one domain without detectable changes in the other dendritic domains. We then investigated the effects of genetically raising the intrinsic excitability of new neurons on their synaptic development by delivering a voltage-gated sodium channel that triggers long depolarizations. Surprisingly, genetically increasing excitability did not affect synaptic development but rescued the changes in glutamatergic input synapses caused by sensory deprivation. These experiments show that, during adult neurogenesis in the olfactory bulb, synaptic plasticity is primarily restricted to an early period during the maturation of new neurons when they are still forming synapses. The addition of cells endowed with such an initial short-lived flexibility and long-term stability may enable the processing of information by the olfactory bulb to be both versatile and reliable in the face of changing behavioral demands. |
| first_indexed | 2024-09-23T16:36:14Z |
| format | Article |
| id | mit-1721.1/55968 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T16:36:14Z |
| publishDate | 2010 |
| publisher | Society for Neuroscience |
| record_format | dspace |
| spelling | mit-1721.1/559682022-10-02T08:24:23Z A critical period for activity-dependent synaptic development during olfactory bulb adult neurogenesis Kelsch, Wolfgang Lin, Chia-Wei Mosley, Colleen P. Lois, Carlos Massachusetts Institute of Technology. Department of Biology Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Picower Institute for Learning and Memory Lois, Carlos Kelsch, Wolfgang Lin, Chia-Wei Mosley, Colleen P. Lois, Carlos New neurons integrate in large numbers into the mature olfactory bulb circuit throughout life. The factors controlling the synaptic development of adult-born neurons and their connectivity remain essentially unknown. We examined the role of activity-dependent mechanisms in the synaptic development of adult-born neurons by genetic labeling of synapses while manipulating sensory input or cell-intrinsic excitability. Sensory deprivation induced marked changes in the density of input and output synapses during the period when new neurons develop most of their synapses. In contrast, when sensory deprivation started after synaptic formation was complete, input synapses increased in one domain without detectable changes in the other dendritic domains. We then investigated the effects of genetically raising the intrinsic excitability of new neurons on their synaptic development by delivering a voltage-gated sodium channel that triggers long depolarizations. Surprisingly, genetically increasing excitability did not affect synaptic development but rescued the changes in glutamatergic input synapses caused by sensory deprivation. These experiments show that, during adult neurogenesis in the olfactory bulb, synaptic plasticity is primarily restricted to an early period during the maturation of new neurons when they are still forming synapses. The addition of cells endowed with such an initial short-lived flexibility and long-term stability may enable the processing of information by the olfactory bulb to be both versatile and reliable in the face of changing behavioral demands. David and Lucile Packard Foundation 2010-06-25T17:22:40Z 2010-06-25T17:22:40Z 2009-09 2009-07 Article http://purl.org/eprint/type/JournalArticle 1529-2401 http://hdl.handle.net/1721.1/55968 Kelsch, Wolfgang et al. “A Critical Period for Activity-Dependent Synaptic Development during Olfactory Bulb Adult Neurogenesis.” J. Neurosci. 29.38 (2009): 11852-11858. © 2009 The Society for Neuroscience https://orcid.org/0000-0002-3470-8125 en_US http://dx.doi.org/10.1523/JNEUROSCI.2406-09.2009 Journal of Neuroscience Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf Society for Neuroscience Society for Neuroscience |
| spellingShingle | Kelsch, Wolfgang Lin, Chia-Wei Mosley, Colleen P. Lois, Carlos A critical period for activity-dependent synaptic development during olfactory bulb adult neurogenesis |
| title | A critical period for activity-dependent synaptic development during olfactory bulb adult neurogenesis |
| title_full | A critical period for activity-dependent synaptic development during olfactory bulb adult neurogenesis |
| title_fullStr | A critical period for activity-dependent synaptic development during olfactory bulb adult neurogenesis |
| title_full_unstemmed | A critical period for activity-dependent synaptic development during olfactory bulb adult neurogenesis |
| title_short | A critical period for activity-dependent synaptic development during olfactory bulb adult neurogenesis |
| title_sort | critical period for activity dependent synaptic development during olfactory bulb adult neurogenesis |
| url | http://hdl.handle.net/1721.1/55968 https://orcid.org/0000-0002-3470-8125 |
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