Inactivation of Drosophila Huntingtin affects long-term adult functioning and the pathogenesis of a Huntington’s disease model

A polyglutamine expansion in the huntingtin (HTT) gene causes neurodegeneration in Huntington’s disease (HD), but the in vivo function of the native protein (Htt) is largely unknown. Numerous biochemical and in vitro studies have suggested a role for Htt in neuronal development, synaptic function an...

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Bibliographic Details
Main Authors: Littleton, J. Troy, Zhang, Sheng, Saraswati, Sudipta, Feany, Mel B., Perrimon, Norbert
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Company of Biologists 2010
Online Access:http://hdl.handle.net/1721.1/56290
https://orcid.org/0000-0001-5576-2887