Hippocampal CA3 Output Is Crucial for Ripple-Associated Reactivation and Consolidation of Memory
A widely held memory consolidation theory posits that memory of events and space is initially stored in the hippocampus (HPC) in a time-limited manner and is consolidated in the neocortex for permanent storage. Although posttraining HPC lesions result in temporally graded amnesia, the precise HPC...
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| Format: | Article |
| Language: | en_US |
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Cell Press
2010
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| Online Access: | http://hdl.handle.net/1721.1/57437 https://orcid.org/0000-0003-2839-8228 |
| _version_ | 1811087234270494720 |
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| author | Tonegawa, Susumu Nakashiba, Toshiaki Buhl, Derek L. McHugh, Thomas J. |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Tonegawa, Susumu Nakashiba, Toshiaki Buhl, Derek L. McHugh, Thomas J. |
| author_sort | Tonegawa, Susumu |
| collection | MIT |
| description | A widely held memory consolidation theory posits that memory of events and space is initially stored in the hippocampus (HPC) in a time-limited manner and is consolidated in the neocortex for permanent storage. Although posttraining HPC lesions result in temporally graded amnesia, the precise HPC circuits and mechanisms involved in remote memory storage remain poorly understood. To investigate the role of the trisynaptic pathway in the consolidation process we employed the CA3-TeTX transgenic mouse, in which CA3 output can be specifically and inducibly controlled. We found that posttraining blockade of CA3 output for up to 4 weeks impairs the consolidation of contextual fear memory. Moreover, in vivo hippocampal recordings revealed a reduced intrinsic frequency of CA1 ripples and a significant decrease in the experience-dependent, ripple-associated coordinated reactivation of CA1 cell pairs. Collectively, these results suggest that the posttraining integrity of the trisynaptic pathway and the ripple-associated reactivation of hippocampal memory engram are crucial for memory consolidation. |
| first_indexed | 2024-09-23T13:41:52Z |
| format | Article |
| id | mit-1721.1/57437 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T13:41:52Z |
| publishDate | 2010 |
| publisher | Cell Press |
| record_format | dspace |
| spelling | mit-1721.1/574372022-09-28T15:37:24Z Hippocampal CA3 Output Is Crucial for Ripple-Associated Reactivation and Consolidation of Memory Tonegawa, Susumu Nakashiba, Toshiaki Buhl, Derek L. McHugh, Thomas J. Massachusetts Institute of Technology. Department of Biology Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Picower Institute for Learning and Memory Tonegawa, Susumu Tonegawa, Susumu Nakashiba, Toshiaki Buhl, Derek L. McHugh, Thomas J. sysneuro molneuro signaling A widely held memory consolidation theory posits that memory of events and space is initially stored in the hippocampus (HPC) in a time-limited manner and is consolidated in the neocortex for permanent storage. Although posttraining HPC lesions result in temporally graded amnesia, the precise HPC circuits and mechanisms involved in remote memory storage remain poorly understood. To investigate the role of the trisynaptic pathway in the consolidation process we employed the CA3-TeTX transgenic mouse, in which CA3 output can be specifically and inducibly controlled. We found that posttraining blockade of CA3 output for up to 4 weeks impairs the consolidation of contextual fear memory. Moreover, in vivo hippocampal recordings revealed a reduced intrinsic frequency of CA1 ripples and a significant decrease in the experience-dependent, ripple-associated coordinated reactivation of CA1 cell pairs. Collectively, these results suggest that the posttraining integrity of the trisynaptic pathway and the ripple-associated reactivation of hippocampal memory engram are crucial for memory consolidation. Otsuka Pharmaceutical Development & Commercialization Inc. 2010-07-20T17:20:30Z 2010-07-20T17:20:30Z 2009-06 2009-05 Article http://purl.org/eprint/type/SubmittedJournalArticle 0896-6273 http://hdl.handle.net/1721.1/57437 Nakashiba, Toshiaki et al. “Hippocampal CA3 Output Is Crucial for Ripple-Associated Reactivation and Consolidation of Memory.” Neuron 62.6 (2009): 781-787. https://orcid.org/0000-0003-2839-8228 en_US http://dx.doi.org/10.1016/j.neuron.2009.05.013 Neuron Attribution-Noncommercial-Share Alike 3.0 Unported http://creativecommons.org/licenses/by-nc-sa/3.0/ application/pdf Cell Press Susumu Tonegawa via Nayiri |
| spellingShingle | sysneuro molneuro signaling Tonegawa, Susumu Nakashiba, Toshiaki Buhl, Derek L. McHugh, Thomas J. Hippocampal CA3 Output Is Crucial for Ripple-Associated Reactivation and Consolidation of Memory |
| title | Hippocampal CA3 Output Is Crucial for Ripple-Associated Reactivation and Consolidation of Memory |
| title_full | Hippocampal CA3 Output Is Crucial for Ripple-Associated Reactivation and Consolidation of Memory |
| title_fullStr | Hippocampal CA3 Output Is Crucial for Ripple-Associated Reactivation and Consolidation of Memory |
| title_full_unstemmed | Hippocampal CA3 Output Is Crucial for Ripple-Associated Reactivation and Consolidation of Memory |
| title_short | Hippocampal CA3 Output Is Crucial for Ripple-Associated Reactivation and Consolidation of Memory |
| title_sort | hippocampal ca3 output is crucial for ripple associated reactivation and consolidation of memory |
| topic | sysneuro molneuro signaling |
| url | http://hdl.handle.net/1721.1/57437 https://orcid.org/0000-0003-2839-8228 |
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