Control of gene expression by cell size
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2010.
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| Format: | Thesis |
| Language: | eng |
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Massachusetts Institute of Technology
2010
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| Online Access: | http://hdl.handle.net/1721.1/57564 |
| _version_ | 1826205789560242176 |
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| author | Wu, Chia-Yung |
| author2 | Gerald R. Fink. |
| author_facet | Gerald R. Fink. Wu, Chia-Yung |
| author_sort | Wu, Chia-Yung |
| collection | MIT |
| description | Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2010. |
| first_indexed | 2024-09-23T13:19:09Z |
| format | Thesis |
| id | mit-1721.1/57564 |
| institution | Massachusetts Institute of Technology |
| language | eng |
| last_indexed | 2024-09-23T13:19:09Z |
| publishDate | 2010 |
| publisher | Massachusetts Institute of Technology |
| record_format | dspace |
| spelling | mit-1721.1/575642019-04-10T11:37:16Z Control of gene expression by cell size Wu, Chia-Yung Gerald R. Fink. Massachusetts Institute of Technology. Dept. of Biology. Massachusetts Institute of Technology. Dept. of Biology. Biology. Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2010. This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections. Cataloged from student submitted PDF version of thesis. Includes bibliographical references. Polyploidy, increased copy number of whole chromosome sets in the genome, is a common cellular state in evolution, development and disease. Polyploidy enlarges cell size and alters gene expression, producing novel phenotypes and functions. Although many polyploid cell types have been discovered, it is not clear how polyploidy changes physiology. Specifically, whether the enlarged cell size of polyploids causes differential gene regulation has not been investigated. In this thesis, I present the evidence for a size-sensing mechanism that alters gene expression in yeast. My results indicate a causal relationship between cell size and gene expression. Ploidy-associated changes in the transcriptome therefore reflect transcriptional adjustment to a larger cell size. The causal and regulatory connection between cell size and transcription suggests that the physical features of a cell (such as size and shape) are a systematic factor in gene regulation. In addition, cell size homeostasis may have a critical function - maintenance of transcriptional homeostasis. by Chia-Yung Wu. Ph.D. 2010-08-26T15:28:47Z 2010-08-26T15:28:47Z 2010 2010 Thesis http://hdl.handle.net/1721.1/57564 654417420 eng M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. http://dspace.mit.edu/handle/1721.1/7582 127 p. application/pdf Massachusetts Institute of Technology |
| spellingShingle | Biology. Wu, Chia-Yung Control of gene expression by cell size |
| title | Control of gene expression by cell size |
| title_full | Control of gene expression by cell size |
| title_fullStr | Control of gene expression by cell size |
| title_full_unstemmed | Control of gene expression by cell size |
| title_short | Control of gene expression by cell size |
| title_sort | control of gene expression by cell size |
| topic | Biology. |
| url | http://hdl.handle.net/1721.1/57564 |
| work_keys_str_mv | AT wuchiayung controlofgeneexpressionbycellsize |