Optimization of Duplex Stability and Terminal Asymmetry for shRNA Design
Prediction of efficient oligonucleotides for RNA interference presents a serious challenge, especially for the development of genome-wide RNAi libraries which encounter difficulties and limitations due to ambiguities in the results and the requirement for significant computational resources. Here we...
Main Authors: | , , , , , , , |
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Other Authors: | |
Format: | Article |
Language: | en_US |
Published: |
Public Library of Science
2010
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Online Access: | http://hdl.handle.net/1721.1/57582 |