Optimization of Duplex Stability and Terminal Asymmetry for shRNA Design

Optimization of Duplex Stability and Terminal Asymmetry for shRNA Design

Prediction of efficient oligonucleotides for RNA interference presents a serious challenge, especially for the development of genome-wide RNAi libraries which encounter difficulties and limitations due to ambiguities in the results and the requirement for significant computational resources. Here we...

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Bibliographic Details
Main Authors: Spiridonov, Alexey Nikolaevich, Matveeva, Olga V., Kang, Yibin, Sætrom, Pål, Nemtsov, Vladimir A., Ogurtsov, Aleksey Y., Nechipurenko, Yury D., Shabalina, Svetlana A.
Other Authors: Massachusetts Institute of Technology. Department of Mathematics
Format: Article
Language:en_US
Published: Public Library of Science 2010
Online Access:http://hdl.handle.net/1721.1/57582

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