Orthogonal Analytical Approaches to Detect Potential Contaminants in Heparin
Heparin is a widely used anticoagulant and antithrombotic agent. Recently, a contaminant, oversulfated chondroitin sulfate (OSCS), was discovered within heparin preparations. The presence of OSCS within heparin likely led to clinical manifestations, most prevalently, hypotension and abdominal pain l...
Main Authors: | , , , , , , , , , |
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Format: | Article |
Language: | en_US |
Published: |
National Academy of Sciences (U.S.)
2010
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Online Access: | http://hdl.handle.net/1721.1/58300 https://orcid.org/0000-0001-9344-0205 https://orcid.org/0000-0002-2085-7840 https://orcid.org/0000-0003-4255-0492 |