Orthogonal Analytical Approaches to Detect Potential Contaminants in Heparin

Orthogonal Analytical Approaches to Detect Potential Contaminants in Heparin

Heparin is a widely used anticoagulant and antithrombotic agent. Recently, a contaminant, oversulfated chondroitin sulfate (OSCS), was discovered within heparin preparations. The presence of OSCS within heparin likely led to clinical manifestations, most prevalently, hypotension and abdominal pain l...

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Bibliographic Details
Main Authors: Sasisekharan, Ram, Guerrini, Marco, Zhang, Zhenqing, Naggi, Annamaria, Masuko, Sayaka, Casu, Casu, Linhardt, Robert J., Torri, Giangiacomo, Shriver, Zachary H., Langer, Robert S
Other Authors: Harvard University--MIT Division of Health Sciences and Technology
Format: Article
Language:en_US
Published: National Academy of Sciences (U.S.) 2010
Subjects:
Anticoagulant
Capillary electrophoresis
Contamination
NMR
Oversulfated chondroitin
Online Access:http://hdl.handle.net/1721.1/58300
https://orcid.org/0000-0001-9344-0205
https://orcid.org/0000-0002-2085-7840
https://orcid.org/0000-0003-4255-0492

Internet

http://hdl.handle.net/1721.1/58300
https://orcid.org/0000-0001-9344-0205
https://orcid.org/0000-0002-2085-7840
https://orcid.org/0000-0003-4255-0492

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