Degrons in Protein Substrates Program the Speed and Operating Efficiency of the AAA+ Lon Proteolytic Machine

Degrons in Protein Substrates Program the Speed and Operating Efficiency of the AAA+ Lon Proteolytic Machine

AAA+ proteases are ATP-fueled machines that bind protein substrates via a degradation tag, unfold the molecule if necessary, and then translocate the polypeptide into a chamber for proteolysis. Tag recognition is normally viewed as a passive reaction. By contrast, for the AAA+ Lon protease, we show...

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Bibliographic Details
Main Authors: Gur, Eyal, Sauer, Robert T
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: National Academy of Sciences (U.S.) 2010
Subjects:
AAA+ protease
Allosteric control
Degradation tags
Online Access:http://hdl.handle.net/1721.1/58301
https://orcid.org/0000-0002-1719-5399

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