Regulation of gene expression and cell state in embryonic stem cells
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, June 2010.
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| Format: | Thesis |
| Language: | eng |
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Massachusetts Institute of Technology
2010
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| Online Access: | http://hdl.handle.net/1721.1/58526 |
| _version_ | 1826207280669917184 |
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| author | Newman, Jamie Jennifer |
| author2 | Richard A. Young. |
| author_facet | Richard A. Young. Newman, Jamie Jennifer |
| author_sort | Newman, Jamie Jennifer |
| collection | MIT |
| description | Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, June 2010. |
| first_indexed | 2024-09-23T13:46:53Z |
| format | Thesis |
| id | mit-1721.1/58526 |
| institution | Massachusetts Institute of Technology |
| language | eng |
| last_indexed | 2024-09-23T13:46:53Z |
| publishDate | 2010 |
| publisher | Massachusetts Institute of Technology |
| record_format | dspace |
| spelling | mit-1721.1/585262019-04-11T06:27:33Z Regulation of gene expression and cell state in embryonic stem cells Newman, Jamie Jennifer Richard A. Young. Massachusetts Institute of Technology. Dept. of Biology. Massachusetts Institute of Technology. Dept. of Biology. Biology. Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, June 2010. "May 2010." Cataloged from PDF version of thesis. Includes bibliographical references. Cell state is established and maintained through the combined action of transcription factors, chromatin regulators and signaling pathways, which all contribute to a transcriptional regulatory circuitry. Embryonic stem (ES) cells are capable of self-renewal and can give rise to nearly all differentiated cell-types, making them an ideal system in which to address the challenges of understanding gene expression and cell state. Valuable insights into the control of cell state have been revealed by recent studies of the ES cell transcriptional regulatory circuitry. Here I present work contributing to the understanding of transcriptional regulatory mechanisms that control ES cell state, specifically signaling pathways and proteins that affect chromatin structure. by Jamie J. Newman. Ph.D. 2010-09-13T14:09:33Z 2010-09-13T14:09:33Z 2010 Thesis http://hdl.handle.net/1721.1/58526 654127676 eng M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. http://dspace.mit.edu/handle/1721.1/7582 224 p. application/pdf Massachusetts Institute of Technology |
| spellingShingle | Biology. Newman, Jamie Jennifer Regulation of gene expression and cell state in embryonic stem cells |
| title | Regulation of gene expression and cell state in embryonic stem cells |
| title_full | Regulation of gene expression and cell state in embryonic stem cells |
| title_fullStr | Regulation of gene expression and cell state in embryonic stem cells |
| title_full_unstemmed | Regulation of gene expression and cell state in embryonic stem cells |
| title_short | Regulation of gene expression and cell state in embryonic stem cells |
| title_sort | regulation of gene expression and cell state in embryonic stem cells |
| topic | Biology. |
| url | http://hdl.handle.net/1721.1/58526 |
| work_keys_str_mv | AT newmanjamiejennifer regulationofgeneexpressionandcellstateinembryonicstemcells |