Single-molecule denaturation and degradation of proteins by the AAA+ ClpXP protease

Single-molecule denaturation and degradation of proteins by the AAA+ ClpXP protease

This article contains supporting information online at www.pnas.org/cgi/content/full/ 0910484106/DCSupplemental.

Bibliographic Details
Main Authors:	Shin, Yongdae, Brau, Ricardo R., Martin, Andreas, Kenniston, Jon A., Lang, Matthew J., Baker, Tania, Davis, Joseph Harry, Sauer, Robert T
Other Authors:	Massachusetts Institute of Technology. Department of Biological Engineering
Format:	Article
Language:	en_US
Published:	National Academy of Sciences 2010
Subjects:	molecular machine protein degradation single-molecule fluorescence protein unfolding protein translocation
Online Access:	http://hdl.handle.net/1721.1/58579 https://orcid.org/0000-0002-4614-251X https://orcid.org/0000-0002-1719-5399

Similar Items

Polypeptide translocation by the AAA+ ClpXP protease machine
by: Barkow, Sarah R., et al.
Published: (2012)

Multistep substrate binding and engagement by the AAA+ ClpXP protease
by: Saunders, Reuben A, et al.
Published: (2021)

Stepwise Unfolding of a β Barrel Protein by the AAA+ ClpXP Protease
by: Nager, Andrew Ross, et al.
Published: (2015)

Structural Principles of Substrate Recognition and Unfolding by the ClpAP and ClpXP AAA+ Proteases
by: Kim, Sora
Published: (2022)

Mechanistic studies of the AAA+ molecular motor ClpXP
by: Barkow, Sarah Rebecca
Published: (2009)

Regulation of Antimycin Biosynthesis Is Controlled by the ClpXP Protease
by: Bilyk, Bohdan, et al.
Published: (2021)

Structure and function of ClpXP, a AAA+ proteolytic machine powered by probabilistic ATP hydrolysis
by: Sauer, Robert T, et al.
Published: (2023)

ClpXP, an ATP-powered unfolding and protein-degradation machine
by: Baker, Tania, et al.
Published: (2014)

Single molecule fluorescence spectroscopy of ClpXP-mediated substrate degradation
by: Shin, Yongdae
Published: (2010)

Substrate selection by the ClpXP protease : a tail of destruction
by: Flynn, Julia M., 1976-
Published: (2005)

Stochastic but Highly Coordinated Protein Unfolding and Translocation by the ClpXP Proteolytic Machine
by: Cordova, Juan Carlos, et al.
Published: (2017)

Dissecting the steps of substrate processing by the energy-dependent protease ClpXP
by: Siddiqui, Samia M. (Siddiqui Mohammed), 1977-
Published: (2006)

Highly Dynamic Interactions Maintain Kinetic Stability of the ClpXP Protease During the ATP-Fueled Mechanical Cycle
by: Sello, Jason K., et al.
Published: (2017)

Structural basis of ClpXP recognition and unfolding of ssrA-tagged substrates
by: Fei, Xue, et al.
Published: (2022)

Structural basis of ClpXP recognition and unfolding of ssrA-tagged substrates
by: Fei, Xue, et al.
Published: (2021)

Structures of the ATP-fueled ClpXP proteolytic machine bound to protein substrate
by: Fei, Xue, et al.
Published: (2022)

Structures of the ATP-fueled ClpXP proteolytic machine bound to protein substrate
by: Fei, Xue, et al.
Published: (2021)

Controlled degradation by ClpXP protease tunes the levels of the excision repair protein UvrA to the extent of DNA damage
by: Pruteanu, Mihaela, et al.
Published: (2014)

AAA+ proteases: the first line of defense against mitochondrial damage
by: Gautam Pareek
Published: (2022-11-01)

The Bacterial ClpXP-ClpB Family Is Enriched with RNA-Binding Protein Complexes
by: Georg Auburger, et al.
Published: (2022-08-01)

Conformational Stability and Denaturation Processes of Proteins Investigated by Electrophoresis under Extreme Conditions
by: Patrick Masson, et al.
Published: (2022-10-01)

Assaying the kinetics of protein denaturation catalyzed by AAA+ unfolding machines and proteases
by: Baytshtok, Vladimir, et al.
Published: (2015)

Unfolded proteins : from denatured to intrinsically disordered /
by: Creamer, Trevor P.
Published: (c200)

Modular and coordinated activity of AAA+ active sites in the double-ring ClpA unfoldase of the ClpAP protease
by: Zuromski, Kristin L, et al.
Published: (2021)

Experimental procedures to investigate fibrillation of proteins
by: Chinmaya Panda, et al.
Published: (2023-12-01)

Identifying the requirement and mechanism of the dynamic yet kinetically stable ClpXP interface
by: Amor, Alvaro Jorge
Published: (2017)

The role of ClpXP-mediated proteolysis in resculpting the proteome after DNA damage
by: Neher, Saskia B. (Saskia Byerly)
Published: (2006)

The Intrinsically Disordered N-terminal Extension of the ClpS Adaptor Reprograms Its Partner AAA + ClpAP Protease
by: Torres-Delgado, Amaris, et al.
Published: (2021)

Patterns in Dried Droplets to Detect Unfolded BSA
by: Yojana J. P. Carreón, et al.
Published: (2022-02-01)

Structural insights into the Clp protein degradation machinery
by: Xiaolong Xu, et al.
Published: (2024-04-01)

NOA1, a Novel ClpXP Substrate, Takes an Unexpected Nuclear Detour Prior to Mitochondrial Import
by: Al-Furoukh, Natalie, et al.
Published: (2014)

Role of communication between subunits and enzymes in ClpXP-mediated substrate unfolding and degradation
by: Joshi, Shilpa Arun, 1975-
Published: (2005)

NEMF-mediated Listerin-independent mitochondrial translational surveillance by E3 ligase Pirh2 and mitochondrial protease ClpXP
by: Liang Lv, et al.
Published: (2024-03-01)

Relation between denaturation and some functional properties of soybean protein /
by: 429072 Katsugi Shiga, et al.

The ClpS Adaptor Mediates Staged Delivery of N-End Rule Substrates to the AAA+ ClpAP Protease
by: Hou, Jennifer Y., et al.
Published: (2014)

Thioredoxin‐interacting protein regulates protein disulfide isomerases and endoplasmic reticulum stress
by: Samuel Lee, et al.
Published: (2014-05-01)

From the unfolded protein response to metabolic diseases – lipids under the spotlight
by: Ho, Nurulain, et al.
Published: (2018)

TRIM44, a Novel Prognostic Marker, Supports the Survival of Proteasome-Resistant Multiple Myeloma Cells
by: Trung Vu, et al.
Published: (2024-08-01)

Novel Anticancer Capacities of Saffron
by: Amr Amin
Published: (2017-11-01)

Development of a GFP biosensor reporter for the unfolded protein response-signaling pathway in plants: incorporation of the bZIP60 intron into the GFP gene
by: Rina Carrillo, et al.
Published: (2022-12-01)